Hyaluronidase expression by an oncolytic adenovirus enhances its intratumoral spread and supresses tumor growth 

Guedán Carrió, Sònia; Rojas, Juan José; Gros Vidal, Alena; Mercadé Gil, M. Elena; Cascalló Piqueras, Manel; Alemany Bonastre, Ramon (2020-05-28)

Successful virotherapy requires efficient virus spread within tumors. We tested whether the expression of hyaluronidase, an enzyme which dissociates the extra-cellular matrix (ECM), could enhance the intratumoral distribution ...