Recent submissions

A single-arm study design with non-inferiority and superiority time-to-event endpoints: a tool for proof-of-concept and de-intensification strategies in breast cancer

Sampayo-Cordero, Miguel; Miguel-Huguet, Bernat; Malfettone, Andrea; López-Miranda, Elena; Gion, María; Abad, Elena; Cortes, Javier (Publication date: 2023-08-30)

Clinical trial; Single-arm; Superiority

Circulating cell-free and extracellular vesicles-derived microRNA as prognostic biomarkers in patients with early-stage NSCLC: results from RESTING study

Petracci, Elisabetta; Pasini, Luigi; Urbini, Milena; stella, franco; Davoli, Fabio; FELIP, ENRIQUETA (Publication date: 2025-02-14)

MicroRNA; Extracellular vesicles; Prognostic biomarkers

Reporting reimbursement price decisions for onco-hematology drugs in Spain

Elvira-Martinez, David; Torres, Ferran; Puig, Gemma; Obach, Merce; Gay, Daniel; Vives, Roser; Tabernero, Josep (Publication date: 2023-11-21)

Health technology assessment; Onco-hematologic prices; Price and reimbursement systems

European screening platform for EORTC clinical trials in advanced colorectal cancer ‘SPECTAcolor’

Folprecht, Gunnar; Morfouace, Marie; Collienne, Maike; Salazar, Ramon; Stein, Alexander; Elez, Elena (Publication date: 2025-06-04)

Screening platform; Colorectal cancers; Targeted treatment

Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer

Pascual Reguant, Laura; Serra Camprubí, Queralt; Datta, Debayan; Cianferoni, Damiano; Kourtis, Savvas; Gañez Zapater, Antoni; Miró Canturri, Andrea; Guzman Torres, Marta; Rodríguez, Olga; Querol, Jessica; Herencia Ropero, Andrea; Arribas, Joaquin; Serra, Violeta; TIAN, TIAN; Peiró, Sandra (Publication date: 2023-12-20)

Cell cycle; Gene expression; Triple-negative breast cancer

p27Kip1 V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor–positive breast cancer

Mouron, Silvana; Bueno, MJ; Muñoz, Manuel; Torres, Raul; Rodriguez, Sandra; Apala, Juan V.; Malumbres Martinez, Marcos (Publication date: 2023-04-25)

Biomarker; Hormone receptor-positive; Breast cancer

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Maus, Mate; Zacharioudakis, Emmanouil; Lafarga, Miguel; Madeira Marques, Francisco; López Polo, Vanessa; Stephan-Otto Attolini, Camille (Publication date: 2025-02-18)

Mitochondrial dsRNA; Cytosol; Inflammatory phenotype

Anthracyclines Strike Back: Rediscovering Non-Pegylated Liposomal Doxorubicin in Current Therapeutic Scenarios of Breast Cancer

Schettini, Francesco; Giuliano, Mario; Bartsch, Rupert; Pinato, David James; Onesti, Concetta Elisa; Cortés Castan, Javier; Lambertini, Matteo (Publication date: 2022-03-15)

Antraciclines; Càncer de mama; Receptor hormonal

A combinatorial culture strategy to develop pseudomyxoma peritonei organoid models

Varinelli, Luca; Di Bella, Marzia; Guaglio, Marcello; Battistessa, Davide; Pisati, Federica; Cavalleri, Tommaso; Martinez-Quintanilla, Jordi (Publication date: 2025-02-18)

Appendiceal tumors; Organoids; Pseudomyxoma peritonei

Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy

Somara, Sasikala; Ko, Heidi; Thatai, Purva; Wallen, Zachary; Saini, Kamal S.; Quintana, Angela (Publication date: 2024-12-04)

Diagnostic biomarker; Head and neck cancer; Squamous cell cancer

Prognostic and predictive impact of gene expression in node-positive early breast cancer patients receiving dose-dense versus standard-dose adjuvant chemotherapy

Reinisch, Mattea; Bruzas, Simona; Gluz, Oleg; Ataseven, Beyhan; Schmid, Peter; Cortes, Javier (Publication date: 2023-07-05)

Adjuvant chemotherapy; Early breast cancer; Lymph node-positive

Young oncologists' perspective on the role and future of the clinician-scientist in oncology

Lim, Kok Haw Jonathan; Westphalen, Benedikt; Berghoff, Anna Sophie; Cardone, Claudia; Connolly, E. A.; Guven, Deniz Can; Mateo, Joaquin (Publication date: 2023-09-14)

Jóvenes oncólogos; Oncología

Multimodal Analysis of the Visual Pathways in Friedreich's Ataxia Reveals Novel Biomarkers

Thomas-Black, Gilbert; Altmann, Daniel; Crook, Harry; Solanky, Nita; Battiston, Marco; Grussu, Francesco; Prados Carrasco, Ferran (Publication date: 2023-10-09)

Friedreich's ataxia; MRI; Biomarkers

Oral metronomic vinorelbine combined with endocrine therapy in hormone receptor-positive HER2-negative breast cancer: SOLTI-1501 VENTANA window of opportunity trial

Adamo, Barbara; Pascual, Tomás; Vidal, Maria; Pérez Fidalgo, José A; Gómez Pardo, Patricia; Paré, Laia; Bellet Ezquerra, Meritxell (Publication date: 2020-07-08)

Breast cancer; Metronomic; Vinorelbine

Olutasidenib (FT-2102) in patients with relapsed or refractory IDH1-mutant glioma: A multicenter, open-label, phase Ib/II trial

de la Fuente, Macarena; Colman, Howard; Rosenthal, Mark; Van Tine, Brian; Levacic, Danijela; Walbert, Tobias; Vieito Villar, Maria (Publication date: 2023-02-14)

Brain penetration; Mutant; Olutasidenib

Recommendations for the Clinical Approach to Immune Thrombocytopenia: Spanish ITP Working Group (GEPTI)

Canaro Hirnyk, Mariana; Sánchez-González, Blanca; Álvarez Román, María Teresa; Bárez-García, Abelardo; Bernardo, Angel; Mingot Castellano, María Eva; VALCARCEL, DAVID (Publication date: 2023-11-10)

Glucocorticoids; Intravenous immunoglobulins; Primary immune thrombocytopenia

Phase I study of CC-90010, a reversible, oral BET inhibitor in patients with advanced solid tumors and relapsed/refractory non-Hodgkin's lymphoma

Sepúlveda, Juan Manuel; Vieito Villar, Maria; Hernández-Guerrero, T.; Doger, B.; Saavedra Gadea, Omar; Braña Garcia, Irene; Moreno, Victor (Publication date: 2021-09-16)

Inhibidor de BET; Limfoma no Hodgkin; Tumors sòlids

Efficacy and Safety of Avutometinib ± Defactinib in Recurrent Low-Grade Serous Ovarian Cancer: Primary Analysis of ENGOT-OV60/GOG-3052/RAMP 201

Banerjee, Susana; Van Nieuwenhuysen, Els; D'Hondt, Veronique; Monk, Bradley; Clamp, Andrew; Aghajanian, Carol; OAKNIN, ANA (Publication date: 2025-09-16)

Efficacy; Safety; Serous ovarian cancer

HER2DX genomic test in HER2-positive/hormone receptor-positive breast cancer treated with neoadjuvant trastuzumab and pertuzumab: A correlative analysis from the PerELISA trial

DIECI, MARIA VITTORIA; Griguolo, Gaia; Marín-Aguilera, Mercedes; GUARNERI, VALENTINA; Brasó Maristany, Fara; Paré, Laia; Vivancos, Ana (Publication date: 2023-05-17)

Biomarker; Breast cancer; Gene expression

Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment

Glaviano, Antonino; Wander, Seth; Baird, Richard; Yap, Kenneth C. H.; Lam, Hiu Yan; Toi, Masakazu; Serra, Violeta (Publication date: 2024-07-04)

CDK4/6i resistance; Endocrine therapy; Breast cancer

Articles científics - VHIO: Recent submissions

A single-arm study design with non-inferiority and superiority time-to-event endpoints: a tool for proof-of-concept and de-intensification strategies in breast cancer ﻿

Circulating cell-free and extracellular vesicles-derived microRNA as prognostic biomarkers in patients with early-stage NSCLC: results from RESTING study ﻿

Reporting reimbursement price decisions for onco-hematology drugs in Spain ﻿

European screening platform for EORTC clinical trials in advanced colorectal cancer ‘SPECTAcolor’ ﻿

Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer ﻿

p27Kip1 V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor–positive breast cancer ﻿

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells ﻿

Anthracyclines Strike Back: Rediscovering Non-Pegylated Liposomal Doxorubicin in Current Therapeutic Scenarios of Breast Cancer ﻿

A combinatorial culture strategy to develop pseudomyxoma peritonei organoid models ﻿

Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy ﻿

Prognostic and predictive impact of gene expression in node-positive early breast cancer patients receiving dose-dense versus standard-dose adjuvant chemotherapy ﻿

Young oncologists' perspective on the role and future of the clinician-scientist in oncology ﻿

Multimodal Analysis of the Visual Pathways in Friedreich's Ataxia Reveals Novel Biomarkers ﻿

Oral metronomic vinorelbine combined with endocrine therapy in hormone receptor-positive HER2-negative breast cancer: SOLTI-1501 VENTANA window of opportunity trial ﻿

Olutasidenib (FT-2102) in patients with relapsed or refractory IDH1-mutant glioma: A multicenter, open-label, phase Ib/II trial ﻿

Recommendations for the Clinical Approach to Immune Thrombocytopenia: Spanish ITP Working Group (GEPTI) ﻿

Phase I study of CC-90010, a reversible, oral BET inhibitor in patients with advanced solid tumors and relapsed/refractory non-Hodgkin's lymphoma ﻿

Efficacy and Safety of Avutometinib ± Defactinib in Recurrent Low-Grade Serous Ovarian Cancer: Primary Analysis of ENGOT-OV60/GOG-3052/RAMP 201 ﻿

HER2DX genomic test in HER2-positive/hormone receptor-positive breast cancer treated with neoadjuvant trastuzumab and pertuzumab: A correlative analysis from the PerELISA trial ﻿

Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment ﻿