Drawing upon 4 initiatives of social innovation embedded in two disenfranchised neighbourhoods: Nou Barris Nord and Sants in Barcelona (Spain), we illustrate different ways in which bottom-up processes can contribute to neighbourhood resilience. The paper explores the nature of social change by bringing together systemic approaches to social innovation and relational theories of collective leadership. In this vein, it is argued that both contextual neighbourhood features and collective leadership practices dialectically explain not only how and why social innovation initiatives emerge but also their social impact in terms of effectiveness and scalability.