Title:
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Recovery of Free Energy Branches in Single Molecule Experiments
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Author:
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Junier, Ivan; Mossa, Alessandro; Mañosas Castejón, María; Ritort Farran, Fèlix
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Other authors:
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Universitat de Barcelona |
Abstract:
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We present a method for determining the free energy of coexisting states from irreversible work measurements. Our approach is based on a fluctuation relation that is valid for dissipative transformations in partially equilibrated systems. To illustrate the validity and usefulness of the approach, we use optical tweezers to determine the free energy branches of the native and unfolded states of a two-state molecule as a function of the pulling control parameter. We determine, within 0.6 k B T accuracy, the transition point where the free energies of the native and the unfolded states are equal. |
Subject(s):
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-Física de partícules -Experiments -Particle physics -Experiments |
Rights:
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(c) American Physical Society, 2009
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Document type:
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Article Article - Published version |
Published by:
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American Physical Society
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