Combined urban drainage system (CUDS) collect both wastewater and raining water through sewer networks to wastewater treatment plants (WWTP) before releasing to the environment. During storm weather, rain and wastewater can overload the capacity of the CUDS and/or the WWTPs, producing combined sewer overflows (CSO). In order to improve the management efficiency of CUDS, advanced real-time control (RTC) of detention and diversion infrastructures in the sewer systems has been proven to contribute to reducing the CSO volumes. This work considers the integrated RTC of sewer network and WWTPs based on model predictive control (MPC) and taking into account the water quality as well as quantity, with the objective of minimizing the environmental impact of CSO on receiving waters. The control approach is validated using a real pilot Badalona sewer network in Spain. The first results, discussion and conclusions are also provided.