Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography

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dc.contributor.author	Gonzalez-Tendero, Anna
dc.contributor.author	Zhang, Chong
dc.contributor.author	Balicevic, Vedrana
dc.contributor.author	Cárdenes, Rubén
dc.contributor.author	Loncaric, Sven
dc.contributor.author	Butakoff, Constantine
dc.contributor.author	Paun, Bruno
dc.contributor.author	Bonnin, Anne
dc.contributor.author	Garcia Canadilla, Patricia
dc.contributor.author	Muñoz-Moreno, Emma
dc.contributor.author	Gratacós Solsona, Eduard
dc.contributor.author	Crispi Brillas, Fàtima
dc.contributor.author	Bijnens, Bart
dc.date	2017
dc.identifier.citation	Gonzalez-Tendero A, Zhang C, Balicevic V, Cárdenes R, Loncaric S, Butakoff C, Paun B, Bonnin A, Garcia-Cañadilla P, Muñoz-Moreno E, Gratacós E, Crispi F, Bijnens B. Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 1;18(7):732-41. DOI: 10.1093/ehjci/jew314
dc.identifier.citation	2047-2404
dc.identifier.citation	https://dx.doi.org/10.1093/ehjci/jew314
dc.identifier.uri	http://hdl.handle.net/10230/36969
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation	European Heart Journal: Cardiovascular Imaging. 2017 Jul 1;18(7):732-41.
dc.relation	info:eu-repo/grantAgreement/ES/3PN/SAF2012-37196
dc.relation	info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
dc.relation	info:eu-repo/grantAgreement/EC/FP7/611823
dc.rights	© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record Gonzalez-Tendero A, Zhang C, Balicevic V, Cárdenes R, Loncaric S, Butakoff C, Paun B, Bonnin A, Garcia-Cañadilla P, Muñoz-Moreno E, Gratacós E, Crispi F, Bijnens B. Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 1;18(7):732-41 is available online at: https://dx.doi.org/10.1093/ehjci/jew314
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Myocardial remodelling
dc.subject	Myofibre structure
dc.subject	Coronary vasculature
dc.subject	Synchrotron phase-contrast CT
dc.title	Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels.
dc.description.abstract	This study was partly supported by Ministerio de Economia y Competitividad (SAF2012-37196;TIN2014-52923-R); Instituto de Salud Carlos III (PI11/00051, PI11/01709, PI12/00801, PI14/00226) integrados en el Plan Nacional de I + D+I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) ‘Otra manera de hacer Europa’; the EU-FP7 for research, technological development and demonstration under grant agreement VP2HF (no611823); The Cerebra Foundation for the Brain Injured Child (Carmarthen, UK); Obra Social ‘la Caixa’ (Barcelona, Spain); Fundació Mutua Madrileña and Fundació Agrupació Mutua (Spain).

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