Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography

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Título:	Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography
Autor/a:	Gonzalez-Tendero, Anna; Zhang, Chong; Balicevic, Vedrana; Cárdenes, Rubén; Loncaric, Sven; Butakoff, Constantine; Paun, Bruno; Bonnin, Anne; Garcia Canadilla, Patricia; Muñoz-Moreno, Emma; Gratacós Solsona, Eduard; Crispi Brillas, Fàtima; Bijnens, Bart
Abstract:	While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels.
Abstract:	This study was partly supported by Ministerio de Economia y Competitividad (SAF2012-37196;TIN2014-52923-R); Instituto de Salud Carlos III (PI11/00051, PI11/01709, PI12/00801, PI14/00226) integrados en el Plan Nacional de I + D+I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) ‘Otra manera de hacer Europa’; the EU-FP7 for research, technological development and demonstration under grant agreement VP2HF (no611823); The Cerebra Foundation for the Brain Injured Child (Carmarthen, UK); Obra Social ‘la Caixa’ (Barcelona, Spain); Fundació Mutua Madrileña and Fundació Agrupació Mutua (Spain).
Materia(s):	-Myocardial remodelling -Myofibre structure -Coronary vasculature -Synchrotron phase-contrast CT
Derechos:	© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record Gonzalez-Tendero A, Zhang C, Balicevic V, Cárdenes R, Loncaric S, Butakoff C, Paun B, Bonnin A, Garcia-Cañadilla P, Muñoz-Moreno E, Gratacós E, Crispi F, Bijnens B. Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 1;18(7):732-41 is available online at: https://dx.doi.org/10.1093/ehjci/jew314
Tipo de documento:	Artículo Artículo - Versión aceptada
Editor:	Oxford University Press
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