The renovation of existing buildings is one of the priorities of western countries and needs to be promoted to increase the current low renovation rate, estimated to be of 0.6% per year in the European and Swiss contexts. In parallel, the implementation of building-integrated photovoltaic (BIPV) elements during the renovation process can provide a crucial response to achieve the 2050 targets in terms of greenhouse gas (GHG) emissions and energy savings. In this context, architects, designers and engineers have a key role in achieving these objectives, mainly because they are responsible for the design decisions during the development of the projects, especially during the early-design phase when the most influential decisions are taken. Through a real-case study built in 1968, this research shows how certain design-decisions in renovation processes can affect or compromise the final performance of the building from a global life-cycle and multi-criteria approach. Life-Cycle Analysis (LCA) and Cost (LCC) results show the importance of not losing the opportunity to go beyond current practices when a building needs to be renovated and highlight the necessity to take into consideration BIPV strategies to guarantee both economic and environmental targets.