We have investigated self-bound ultradilute bosonic binary mixtures at zero temperature within density functional theory using a local density approximation. We provide the explicit expression of the Lee-Huang-Yang correction in the general case of heteronuclear mixtures, and investigate the general thermodynamic conditions which lead to the formation of self-bound systems. We have determined the conditions for stability against the evaporation of one component, as well as the mechanical and diffusive spinodal lines. We have also calculated the surface tension of the self-bound state as a function of the interspecies interaction strength. We find that relatively modest variations of the latter result in order-of-magnitude changes in the calculated surface tension. We suggest experimental realizations which might display the metastability and phase separation of the mixture when entering regions of the phase diagram characterized by negative pressures. Finally, we show that these droplets may sustain stable vortex and vortex pairs.