Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes

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RECERCAT Home > Universitat de Barcelona > Química Inorgànica i Orgànica > Articles publicats en revistes (Química Inorgànica i Orgànica) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/128561

dc.contributor	Universitat de Barcelona
dc.contributor.author	Gavara, Raquel
dc.contributor.author	Aguiló Linares, Elisabet
dc.contributor.author	Schur, J.
dc.contributor.author	Llorca, Jordi, 1966-
dc.contributor.author	Ott, Ingo
dc.contributor.author	Rodríguez, Laura
dc.date	2019-02-20T15:22:59Z
dc.date	2019-02-20T15:22:59Z
dc.date	2016-03-14
dc.date	2019-02-20T15:22:59Z
dc.identifier.citation	0020-1693
dc.identifier.citation	661688
dc.identifier.uri	http://hdl.handle.net/2445/128561
dc.format	9 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier B.V.
dc.relation	Versió postprint del document publicat a: https://doi.org/10.1016/j.ica.2016.03.012
dc.relation	Inorganica Chimica Acta, 2016, vol. 446, p. 189-197
dc.relation	https://doi.org/10.1016/j.ica.2016.03.012
dc.rights	cc-by-nc-nd (c) Elsevier B.V., 2016
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.subject	Or
dc.subject	Compostos organometàl·lics
dc.subject	Gold
dc.subject	Organometallic compounds
dc.title	Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	The synthesis and characterization of four organometallic gold(I) complexes containing different water soluble phosphanes (TPPTS, PTA and DAPTA) and chromophoric units (4-pyridylethynyl and propargyloxycoumarin) is here reported. The analysis of their absorption and emission spectra led us to attribute their luminescent behavior to the chromophoric organic ligands. Moreover, the presence of the gold(I) metal atom has been observed to be the responsible of an efficient intersystem crossing process responsible for the observed phosphorescence emission. Broad emission bands are observed in most cases due to the formation of organized aggregates in solution in agreement with microscopic characterization. Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR). The missing/low cytotoxic effects could be related to a low bioavailability as determined by atomic absorption spectroscopy. Graphical abstract The synthesis, characterization, aggregation and emissive properties of four organometallic gold(I) complexes containing different water soluble phosphanes and chromophoric units is here reported. Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR)

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