Autor/a:
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Huerta Castaño, José María; Chirlaque, María Dolores; Molina de la Torre, Antonio José; Amiano, Pilar; Martín Sánchez, Vicente; Fernández Villa, Tania; Pérez Gómez, Beatriz; Moreno Aguado, Víctor; Burgui, Rosana; Gómez Acebo, Inés; Ramos Lora, Manuel; Fernández Tardón, Guillermo; Peiró Pérez, Rosana; Olmedo Requena, Rocío; Pollán, Marina; Kogevinas, Manolis; Castaño-Vinyals, Gemma; Aragonès Sanz, Núria
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Abstract:
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BACKGROUND: Evidence for a protective role of physical activity
against development of stomach cancer is yet inconclusive. We
studied the association of domain-specific physical activity and
the risk of gastric adenocarcinoma (GAC), by site and histology,
in the MCC-Spain case-control study. METHODS: 428 histologically
confirmed GAC cases (67% men) including the gastro-esophageal
region and 3225 controls were included. Cases were recruited in
hospitals from 10 different Spanish regions, whereas population
controls were randomly selected within the respective hospitals'
catchment areas. A physical activity (PA) questionnaire was used
to gather information on household and recreational activities,
allowing estimation of PA volume (in metabolic equivalents
(MET)-min/week). Participants also reported the intensity of
working PA and daily sitting time. Questionnaire data on diet,
lifestyles and clinical variables including Helicobacter pylori
serology were available. Adjusted odds ratios (OR) of GAC were
estimated for domains of physical activity, stratifying by sex,
site (cardia vs. non-cardia), and Lauren classification
(intestinal vs. diffuse). RESULTS: Household physical activity
(HPA) showed a strong inverse association with GAC, observed for
both cardia and non-cardia tumours. Risk of overall gastric
cancer was 50% lower risk among participants in the highest HPA
category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical
activity (RPA) was also associated with lower overall GAC risk
(OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels
of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79).
The protective effect of RPA was strongest for non-cardia
tumours. Sedentary time was not related to GAC risk (p-trend =
0.392), but the potential protective effect of RPA was
restricted to non-sedentary participants. CONCLUSIONS: Both
household and recreational physical activities were
independently related to lower GAC risk in the MCC-Spain study. |