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Título: | Critical comparison of shake-flask, potentiometric and chromatographic methods for lipophilicity evaluation (log Po/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs |
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Autor/a: | Port, Ariadna; Bordas, Magda; Enrech, Raquel; Pascual, Rosalía; Rosés Pascual, Martí; Ràfols Llach, Clara; Subirats i Vila, Xavier; Bosch, Elisabeth |
Otros autores: | Universitat de Barcelona |
Abstract: | In the present study three different procedures have been compared for the determination of the lipophilicity of the unionized species (log Po/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs. Shake-flask, potentiometric and chromatographic approaches have been assayed in a set of 66 representative compounds in different phases of advanced development. An excellent equivalence has been found between log Po/w values obtained by shake-flask and potentiometry, while the chromatographic approach is less accurate but very convenient for screening purposes when a high-throughput is required. In the case of zwitterionic and amphoteric compounds, either for shake-flask and chromatographic methods, the pH has to be accurately selected in order to ensure the compound to be in its neutral form. |
Materia(s): | -Lipofília -Cromatografia de líquids -Potenciòmetres -Concentració dels ions d'hidrogen -Lipophilicity -Liquid chromatography -Potentiometer -Hydrogen-ion concentration |
Derechos: | cc-by-nc-nd (c) Elsevier B.V., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es |
Tipo de documento: | Artículo Artículo - Versión aceptada |
Editor: | Elsevier B.V. |
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