Títol:
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Shared latent structures between imaging features and biomarkers in early stages of Alzheimer's disease
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Autor/a:
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Casamitjana Díaz, Adrià; Vilaplana Besler, Verónica; Petrone, Paula; Molinuevo, Jose Luis; Gispert, Juan Domingo
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Altres autors:
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Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions; Universitat Politècnica de Catalunya. GPI - Grup de Processament d'Imatge i Vídeo |
Abstract:
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In this work, we identify meaningful latent patterns in MR images for patients across the Alzheimer’s disease (AD) continuum. For this purpose, we apply Projection to Latent Structures (PLS) method using cerebrospinal fluid (CSF) biomarkers (t-tau, p-tau, amyloid-beta) and age as response variables and imaging features as explanatory variables. Freesurfer pipeline is used to compute MRI surface and volumetric features resulting in 68 cortical ROIs and 84 cortical and subcortical ROIs, respectively. The main assumption of this work is that there are two main underlying processes governing brain morphology along the AD continuum: brain aging and dementia. We use two different and orthogonal PLS models to describe each process: PLS-aging and PLS-dementia. To define PLS-aging model we use normal aging subjects and age as predictor and response variables, respectively, while for PLS-dementia we only use demented subjects and biomarkers as response variables. |
Abstract:
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Peer Reviewed |
Matèries:
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-Àrees temàtiques de la UPC::Enginyeria de la telecomunicació -Àrees temàtiques de la UPC::Ciències de la salut::Medicina -Brain -Alzheimer's disease -PLS -Preclinical AD -Latent model -Cervell -Alzheimer, Malaltia d' |
Drets:
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Tipus de document:
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Article - Versió publicada Objecte de conferència |
Publicat per:
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Springer International Publishing
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