New transcription regulatory mechanisms of latent HIV LTR

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RECERCAT Home > Universitat de Barcelona > Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL) > Articles publicats en revistes (Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL)) > View document

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Title:	New transcription regulatory mechanisms of latent HIV LTR
Author:	Rafati, Haleh; Moshkin, Yuri; Mahmoudi, Tokameh; Parra Bola, Mª Isabel; Hakre, Shweta; Verdin, Eric
Abstract:	Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T cells of infected patients in a latent state, providing the main impediment to eradication of the virus. We are interested in identifying the molecular mechanism responsible for the establishment and maintenance of HIV latency and its re-activation. We recently used a cell system reflecting HIV latency in my lab to determine the high resolution nucleosomal landscape of the latent HIV LTR and examine its dynamic changes upon re-activation (Rafati et al., Nov 2011 PLoS Biology)...
Subject(s):	-VIH (Virus) -Antiretrovirals -HIV (Viruses) -Antiretroviral agents
Rights:	cc by (c) Rafati et al., 2012 http://creativecommons.org/licenses/by/3.0/es/
Document type:	Article Article - Published version
Published by:	BioMed Central
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