A new strategy to minimize magnetic interactions between nanowires (NWs) dispersed in a fluid is proposed. Such a strategy consists of preparing trisegmented NWs containing two antiparallel ferromagnetic segments with dissimilar coercivity separated by a nonmagnetic spacer. The trisegmented NWs exhibit a staircase-like hysteresis loop with tunable shape that depends on the relative length of the soft- and hard-magnetic segments and the respective values of saturation magnetization. Such NWs are prepared by electrodepositing CoPt/Cu/Ni in a polycarbonate (PC) membrane. The antiparallel alignment is set by applying suitable magnetic fields while the NWs are still embedded in the PC membrane. Analytic calculations are used to demonstrate that the interaction magnetic energy from fully compensated trisegmented NWs with antiparallel alignment is reduced compared to a single-component NW with the same length or the trisegmented NWs with the two ferromagnetic counterparts parallel to each other. The proposed approach is appealing for the use of magnetic NWs in certain biological or catalytic applications where the aggregation of NWs is detrimental for optimized performance.