VMS deposits in the Greater Antilles are described throughout the Dominican Republic and Cuba, genetically linked to two main episodes of the island-arc tectonic and magmatic evolution: 1) bimodal mafic type deposits, formed during the earliest stages of island-arc volcanism and 2) mafic (Cyprus) type, formed in mature back-arc basins (Nelson et al., 2011). Bimodal-mafic VMS deposits are in the main hosted in tholeiitic volcanic rocks of Early Cretaceous age of the Maimón and Amina Formations in Cordillera Central of the Dominican Republic and in Los Pasos Formation and Purial Complex in central and eastern Cuba respectively. Mild though decided trend toward Sb enrichment in tennantite from stratiform ores in the San Fernando and Antonio deposits with respect to Cerro de Maimón parallel lower values of Se and As and higher contents in the more incompatibles Sb, Te and Bi in galena. These nuances in ore geochemistry support a slightly more primitive setting of formation of VMS mineralization in the Maimón Formation denoted by the lithogeochemistry of the hosting volcanic units.