Recombinant fibronectin fragment III8-10 / polylactic acid hybrid nanofibers enhance the bioactivity of titanium surface

Home | About RECERCAT | Contact

Català | Castellano

All of RECERCAT

By Communities &
Collections By Defense Date By Authors By Titles By Subject

This Collection

By Defense Date By Authors By Titles By Subject

Statistics

View Statistics All RECERCAT

My RECERCAT

Other repositories directory

RECERCAT Home > Universitat Politècnica de Catalunya > Documents de recerca > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2117/117595

dc.contributor	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor	Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.contributor.author	Guillem Martí, Jordi
dc.contributor.author	Boix Lemonche, Gerard
dc.contributor.author	Gugutkov, Dencho
dc.contributor.author	Ginebra Molins, Maria Pau
dc.contributor.author	Altankov, George Petrov
dc.contributor.author	Manero Planella, José María
dc.date	2018-03-22
dc.identifier.citation	Guillem-Marti, J., Boix-Lemonche, G., Gugutkov, D., Ginebra, M.P., Altankov, G., Manero, J. Recombinant fibronectin fragment III8-10 / polylactic acid hybrid nanofibers enhance the bioactivity of titanium surface. "Nanomedicine", 22 Març 2018, vol. 13, núm. 8, p. 899-912.
dc.identifier.citation	1743-5889
dc.identifier.citation	10.2217/nnm-2017-0342
dc.identifier.uri	http://hdl.handle.net/2117/117595
dc.language.iso	eng
dc.relation	https://www.futuremedicine.com/doi/10.2217/nnm-2017-0342
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria dels materials
dc.subject	Biomedical materials
dc.subject	Nanofibres
dc.title	Recombinant fibronectin fragment III8-10 / polylactic acid hybrid nanofibers enhance the bioactivity of titanium surface
dc.type	info:eu-repo/semantics/submittedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Aim: To develop a nanofiber (NF)-based biomimetic coating on titanium (Ti) that mimics the complex spatiotemporal organization of the extracellular matrix (ECM). Materials & methods:Recombinant cell attachment site (CAS) of fibronectin type III8-10 domain was co-electrospun with polylactic acid (PLA) and covalently bound on polished Ti discs. Osteoblast-like SaOS-2 cells were used to evaluate their complex bioactivity. Results: A significant increase of cell spreading was found on CAS/PLA hybrid NFs, followed by control pure PLA NFs and bare Ti discs. Cell proliferation showed similar trend being about twice higher on CAS/PLA NFs. The significantly increased ALP activity at day 21 indicated an enhanced differentiation of SaOS-2 cells. Conclusion: Coating of Ti implants with hybrid CAS/PLA NFs may improve significantly their osseointegration potential.
dc.description.abstract	Peer Reviewed

Show simple item record

All of RECERCAT

This Collection

Statistics

My RECERCAT

Related documents

Other documents of the same author