dc.contributor.author |
Izquierdo, Javier |
dc.contributor.author |
Ayats, Carles |
dc.contributor.author |
Henseler, Andrea H. |
dc.contributor.author |
Pericàs, Miquel A. |
dc.date.accessioned |
2018-01-15T16:04:37Z |
dc.date.accessioned |
2018-02-15T10:27:58Z |
dc.date.available |
2018-01-15T16:04:37Z |
dc.date.available |
2018-02-15T10:27:58Z |
dc.date.issued |
2015 |
dc.identifier.uri |
http://hdl.handle.net/2072/226369 |
dc.identifier.uri |
http://hdl.handle.net/2072/305809 |
dc.language.iso |
eng |
dc.publisher |
Royal Society of Chemistry |
dc.relation |
MINECO |
dc.relation |
DEC Generalitat de Catalunya |
dc.relation |
Severo Ochoa Excellence Accreditation 2014−2018 |
dc.relation |
Proyectos I+D+I |
dc.relation |
Marie Skłodowska-Curie COFUND |
dc.relation.ispartof |
Organic & Biomolecular Chemistry |
dc.rights |
© The Royal Society of Chemistry 2015 |
dc.title |
A Polystyrene-Supported 9-amino(9-deoxy)epi Quinine Derivative for Continuous Flow Asymmetric Michael Reactions |
dc.type |
info:eu-repo/semantics/article |
dc.relation.projectID |
SEV-2013-0319 |
dc.relation.projectID |
CTQ2012-38594-C02-01 |
dc.relation.projectID |
info:eu-repo/grantAgreement/EC/FP7/291787 (ICIQ-IPMP) |
dc.relation.projectID |
2014 SGR827 |
dc.identifier.doi |
https://dx.doi.org/10.1039/c5ob00325c |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts |