Title:
|
A Polystyrene-Supported 9-amino(9-deoxy)epi Quinine Derivative for Continuous Flow Asymmetric Michael Reactions
|
Author:
|
Izquierdo, Javier; Ayats, Carles; Henseler, Andrea H.; Pericàs, Miquel A.
|
Abstract:
|
A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts |
Publication date:
|
2015 |
Rights:
|
© The Royal Society of Chemistry 2015 |
Document type:
|
Article |
DOI:
|
https://dx.doi.org/10.1039/c5ob00325c
|
Published by:
|
Royal Society of Chemistry
|
Publish at:
|
Organic & Biomolecular Chemistry
|
Share:
|
|