Logic regression analysis of gene polymorphisms and HDL levels in a nationally representative sample of Iranian adolescents: The CASPIAN-III study

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dc.contributor.author	Moghadasi, Mehri
dc.contributor.author	Kelishadi, Roya
dc.contributor.author	Marateb, Hamid Reza
dc.date	2017-01-01
dc.identifier.citation	Moghadasi, M., Kelishadi, R., Marateb, H.R. Logic regression analysis of gene polymorphisms and HDL levels in a nationally representative sample of Iranian adolescents: The CASPIAN-III study. "International Journal of Endocrinology and Metabolism", 1 Gener 2017, vol. 15, p. 1-8.
dc.identifier.citation	1726-9148 1726913X
dc.identifier.citation	10.5812/ijem.14037
dc.identifier.uri	http://hdl.handle.net/2117/112959
dc.language.iso	eng
dc.relation	http://endometabol.com/en/articles/14037.html
dc.rights	Attribution-NonCommercial 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Pediatria
dc.subject	Lipoproteins--genetics
dc.subject	High-Density lipoprotein
dc.subject	Logic regression
dc.subject	Pediatrics
dc.subject	Polymorphism
dc.subject	Lipoproteïnes--Genètica
dc.title	Logic regression analysis of gene polymorphisms and HDL levels in a nationally representative sample of Iranian adolescents: The CASPIAN-III study
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Background: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. Methods: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels. Results: The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels. Conclusions:We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis.
dc.description.abstract	Peer Reviewed

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