Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases

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RECERCAT Principal > Universitat de Barcelona > Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL) > Articles publicats en revistes (Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL)) > Visualizar documento

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dc.contributor.author	Rakislova, Natalia
dc.contributor.author	Clavero, Omar
dc.contributor.author	Alemany i Vilches, Laia
dc.contributor.author	Saco, Adela
dc.contributor.author	Quirós, Beatriz
dc.contributor.author	Lloveras Rubio, Belén
dc.contributor.author	Alejo, Maria
dc.contributor.author	Pawlita, Michael
dc.contributor.author	Quint, Wim
dc.contributor.author	Pino, Marta del
dc.contributor.author	Sanjosé Llongueras, Silvia de
dc.contributor.author	Ordi i Majà, Jaume
dc.date	2017-09-26T10:46:59Z
dc.date	2018-08-31T22:01:24Z
dc.date	2017-08-31
dc.date	2017-09-06T18:00:18Z
dc.identifier.citation	0020-7136
dc.identifier.uri	http://hdl.handle.net/2445/115786
dc.format	37 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Wiley
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.1002/ijc.31006
dc.relation	International Journal of Cancer, 2017, vol. , num. , p. Ahead of print
dc.relation	http://dx.doi.org/10.1002/ijc.31006
dc.rights	(c) Wiley, 2017
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Papil·lomavirus
dc.subject	Malalties de la vulva
dc.subject	Papillomaviruses
dc.subject	Vulva diseases
dc.title	Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	There are at least two different etio-pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent of HPV. We aimed to describe the histological characteristics of HPV-associated and HPV-independent tumors and to determine the best strategy to identify HPV in VSCC. A single paraffin block was available for review from a series of 1594 VSCCs. In all cases HPV DNA detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and p16 immunohistochemistry (IHC). A tumor was considered as unquestionably HPV-associated if both HPV DNA and p16 IHC were positive. A tumor was considered indisputably HPV-independent if both HPV DNA and p16 IHC were negative. Two groups of tumors were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV DNA-/p16+. WHO typing and a thorough histological evaluation were conducted in all cases. 441 tumors were HPV DNA+ with 367 cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors were more frequently basaloid or warty (49.8%), but 36.5% were of the keratinizing type. 1153 tumors were HPV DNA-, with 1060 cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors were mostly keratinizing (81.2%) but were occasionally basaloid or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were similar to those of the HPV-associated VSCC, and HPV DNA+/p16- (n=74) cases had a more diverse profile, although they were more similar to HPV-independent tumors. Several histological characteristics were more frequently associated with HPV-related VSCC (koilocytotic-like change, necrosis, moderate to marked pleomorphism, invasive front in nests; p<0.001), however, none of these characteristics allowed differentiation between HPV-associated and -independent VSCC. In conclusion, histological criteria do not allow differentiation between HPV-associated and -independent VSCC. p16 alone is a clinically easy strategy to determine HPV status in VSCC. This article is protected by copyright. All rights reserved.

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