Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction

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RECERCAT Home > Universitat de Barcelona > Biomedicina > Articles publicats en revistes (Biomedicina) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/112996

dc.contributor	Universitat de Barcelona
dc.contributor.author	Aguiar, Pablo
dc.contributor.author	Pino Sorroche, Francisco
dc.contributor.author	Silva-Rodríguez, Jesús
dc.contributor.author	Pavía Segura, Javier
dc.contributor.author	Ros Puig, Domènec
dc.contributor.author	Ruibal Morell, Álvaro
dc.contributor.author	El Bitar, Ziad
dc.date	2017-06-28T09:19:22Z
dc.date	2017-06-28T09:19:22Z
dc.date	2014-03-03
dc.date	2017-06-28T09:19:22Z
dc.identifier.citation	0094-2405
dc.identifier.citation	646907
dc.identifier.uri	http://hdl.handle.net/2445/112996
dc.description.abstract	PURPOSE: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. METHODS: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. RESULTS: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the projection noise than MC-SRM. CONCLUSIONS: The authors' findings show that both approaches provide good solutions to the problem of calculating the SRM in pinhole SPECT reconstruction. The AE-SRM was faster to create and handle the projection noise better than MC-SRM. Nevertheless, the AE-SRM required a tedious experimental characterization of the intrinsic detector response. Creation of the MC-SRM required longer computation time and handled the projection noise worse than the AE-SRM.Nevertheless, the MC-SRM inherently incorporates extensive modeling of the system and therefore experimental characterization was not required.
dc.format	10 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	American Association of Physicists in Medicine
dc.relation	Reproducció del document publicat a: https://doi.org/10.1118/1.4866380
dc.relation	Medical Physics, 2014, vol. 41, num. 3, p. 32501
dc.relation	https://doi.org/10.1118/1.4866380
dc.rights	(c) American Association of Physicists in Medicine, 2014
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Algorismes
dc.subject	Simulació per ordinador
dc.subject	Mètode de Montecarlo
dc.subject	Programari
dc.subject	Tomografia computada per emissió de fotó simple
dc.subject	Algorithms
dc.subject	Computer simulation
dc.subject	Monte Carlo method
dc.subject	Computer software
dc.subject	Single-photon emission computed tomography
dc.title	Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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