3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine

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dc.contributor	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor	Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.contributor.author	Vila, Mercedes
dc.contributor.author	García, Ana
dc.contributor.author	Girotti, Alessandra
dc.contributor.author	Alonso, Matilde
dc.contributor.author	Rodriguez Cabello, Jose Carlos
dc.contributor.author	Gonzalez Vazquez, Arlyng
dc.contributor.author	Planell Estany, Josep Anton
dc.contributor.author	Engel López, Elisabeth
dc.contributor.author	Buján, Julia
dc.contributor.author	García Honduvilla, Natalio
dc.contributor.author	Vallet Regi, Maria
dc.date	2016-11-01
dc.identifier.citation	Vila, M., García, A., Girotti, A., Alonso, M., Rodriguez-Cabello , J.C., Gonzalez, A., Planell, J., Engel, E., Buján, J., García, N., Vallet-Regi, M. 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine. "Acta biomaterialia", 1 Novembre 2016, vol. 45, p. 349-356.
dc.identifier.citation	1742-7061
dc.identifier.citation	10.1016/j.actbio.2016.09.016
dc.identifier.uri	http://hdl.handle.net/2117/98193
dc.language.iso	eng
dc.relation	http://www.sciencedirect.com/science/article/pii/S1742706116304792
dc.relation	info:eu-repo/grantAgreement/EC/FP7/278557/EU/Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer/THE GRAIL
dc.relation	info:eu-repo/grantAgreement/EC/H2020/646075/EU/Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet%2FCell Niche/ELASTISLET
dc.relation	info:eu-repo/grantAgreement/EC/H2020/642687/EU/Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications/BIOGEL
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria dels materials
dc.subject	Tissue engineering
dc.subject	Regenerative medicine
dc.subject	Biomedical materials
dc.subject	Bone repair
dc.subject	tissue engineering
dc.subject	Elastin-like Recombinamers (ELRs)
dc.subject	Silicon doped hydroxyapatite (Si-HA)
dc.subject	rapid prototyped 3D scaffolds
dc.subject	Bone marrow Mesenchymal Stromal Cells (BMSCs)
dc.subject	Enginyeria de teixits
dc.subject	Medicina regenerativa
dc.subject	Materials biomèdics
dc.title	3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
dc.type	info:eu-repo/semantics/submittedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) functionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineering: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxyapatite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible and bone regeneration properties of calcium phosphates materials. The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts.
dc.description.abstract	Peer Reviewed

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