dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Hong, Jihyung |
dc.contributor.author |
Novick, Diego |
dc.contributor.author |
Treuer, Tamas |
dc.contributor.author |
Montgomery, William |
dc.contributor.author |
Haynes, Virginia S. |
dc.contributor.author |
Wu, Shenghu |
dc.contributor.author |
Haro Abad, Josep Maria |
dc.date |
2015-05-25T09:32:42Z |
dc.date |
2015-05-25T09:32:42Z |
dc.date |
2013-09-30 |
dc.date |
2015-05-25T09:32:42Z |
dc.identifier.citation |
1177-889X |
dc.identifier.citation |
648376 |
dc.identifier.uri |
http://hdl.handle.net/2445/65618 |
dc.format |
9 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Dove Medical Press |
dc.relation |
Reproducció del document publicat a: http://dx.doi.org/10.2147/PPA.S50628 |
dc.relation |
Patient Preference And Adherence, 2013, vol. 7, p. 987-995 |
dc.relation |
http://dx.doi.org/10.2147/PPA.S50628 |
dc.rights |
cc-by-nc (c) Hong, J. et al., 2013 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by-nc/3.0/es |
dc.subject |
Trastorns per dèficit d'atenció amb hiperactivitat en els infants |
dc.subject |
Assaigs clínics |
dc.subject |
Àsia |
dc.subject |
Europa central |
dc.subject |
Attention deficit disorder with hyperactivity in children |
dc.subject |
Clinical trials |
dc.subject |
Asia |
dc.subject |
Central Europe |
dc.title |
Predictors and consequences of adherence to the treatment of pediatric patients with attention-deficit/hyperactivity disorder in Central Europe and East Asia. |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
PURPOSE: To assess baseline predictors and consequences of medication non-adherence in the treatment of pediatric patients with attention-deficit/hyperactivity disorder (ADHD) from Central Europe and East Asia. PATIENTS AND METHODS: Data for this post-hoc analysis were taken from a 1-year prospective, observational study that included a total of 1,068 newly-diagnosed pediatric patients with ADHD symptoms from Central Europe and East Asia. Medication adherence during the week prior to each visit was assessed by treating physicians using a 5-point Likert scale, and then dichotomized into either adherent or non-adherent. Clinical severity was measured by the Clinical Global Impressions-ADHD-Severity (CGI-ADHD) scale and the Child Symptom Inventory-4 (CSI-4) Checklist. Health-Related Quality of Life (HRQoL) was measured using the Child Health and Illness Profile-Child Edition (CHIP-CE). Regression analyses were used to assess baseline predictors of overall adherence during follow-up, and the impact of time-varying adherence on subsequent outcomes: response (defined as a decrease of at least 1 point in CGI), changes in CGI-ADHD, CSI-4, and the five dimensions of CHIP-CE. RESULTS: Of the 860 patients analyzed, 64.5% (71.6% in Central Europe and 55.5% in East Asia) were rated as adherent and 35.5% as non-adherent during follow-up. Being from East Asia was found to be a strong predictor of non-adherence. In East Asia, a family history of ADHD and parental emotional distress were associated with non-adherence, while having no other children living at home was associated with non-adherence in Central Europe as well as in the overall sample. Non-adherence was associated with poorer response and less improvement on CGI-ADHD and CSI-4, but not on CHIP-CE. CONCLUSION: Non-adherence to medication is common in the treatment of ADHD, particularly in East Asia. Non-adherence was associated with poorer response and less improvement in clinical severity. A limitation of this study is that medication adherence was assessed by the treating clinician using a single item question. |