Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice

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dc.contributor.author	Zimmer, Andreas
dc.contributor.author	Valjent, Emmanuel
dc.contributor.author	König, Monika
dc.contributor.author	Zimmer, Anne M.
dc.contributor.author	Robledo, Patricia, 1958-
dc.contributor.author	Hahn, Heidi
dc.contributor.author	Valverde Granados, Olga
dc.contributor.author	Maldonado, Rafael, 1961-
dc.date	2001
dc.identifier.citation	Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldonado R. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001; 21(23): 9499-505. DOI 10.1523/jneurosci.21-23-09499.2001
dc.identifier.citation	0270-6474
dc.identifier.citation	http://dx.doi.org/10.1523/jneurosci.21-23-09499.2001
dc.identifier.uri	http://hdl.handle.net/10230/16667
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Society for Neuroscience
dc.relation	J Neurosci. 2001; 21(23): 9499-505
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	(c) 2001, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/21/23/9499
dc.subject	Cannabinoides -- Efectes fisiològics
dc.subject	Cannabinoides -- Receptors
dc.subject	Cannabinoid
dc.subject	Opioid
dc.subject	Mice
dc.subject	Mutation
dc.subject	Withdrawal
dc.subject	Addiction
dc.subject	Place aversion
dc.title	Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.
dc.description.abstract	This work was supported by European Commission BIOM ED-2 Grant 98-2227 (R.M.), Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S. A. Laboratories (R.M.), Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 400), and the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.)

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