Title:
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Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice
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Author:
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Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas
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Abstract:
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The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence. |
Abstract:
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This work was supported by European Commission Grant BIOM ED-2/98–2227 and Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S.A. Laboratories, and La Fondation des Treilles, and by a grant from the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.). |
Subject(s):
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-Cannabinoides -- Efectes fisiològics -Cannabinoides -- Receptors -Drogoaddicció -- Aspectes moleculars -Cannabinoid -Opioid -Mice -Mutation -Withdrawal -Addiction -Tolerance |
Rights:
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(c) 2000, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/20/24/9284 |
Document type:
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Article Article - Published version |
Published by:
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Society for Neuroscience
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