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Título:	A low elastic modulus Ti-Nb-Hf alloy bioactivated with an elastin-like
Autor/a:	González, Marta; Salvagni, Emiliano; Rodríguez Cabello, J.C.; Rupérez de Gracia, Elisa; Gil Mur, Francisco Javier; Manero Planella, José María; Peña, Javier
Otros autores:	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. CDAL - Centre de Disseny d'Aliatges Lleugers i Tractaments de Superfície; Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits; Universidad de Valladolid
Abstract:	b-type titanium alloys with low Young’s modulus are desirable to reduce stress shielding effect and enhance bone remodeling for implants used to substitute failed hard tissue. For biomaterials application, the surface bioactivity is necessary to achieve optimal osseointegration. In the previous work, the low elastic modulus (43 GPa) Ti-25Nb-16Hf (wt %) alloy was mechanically and microstructurally characterized. In the present work, the biological behavior of Ti-25Nb- 16Hf was studied. The biological response was improved by surface modification. The metal surface was modified by oxygen plasma and subsequently silanized with 3-chloropropyl (triethoxy)silane for covalent immobilization of the elastin-like polymer. The elastin-like polymer employed exhibits RGD bioactive motives inspired to the extracellular matrix in order to improve cell adhesion and spreading. Upon modification, the achieved surface presented different physical and chemical properties, such as surface energy and chemical composition. Subsequently, osteoblast adhesion, cell numbers, and differentiation studies were performed to correlate surface properties and cell response. The general tendency was that the higher surface energy the higher cell adhesion. Furthermore, cell culture and immunofluorescence microscopy images demonstrated that RGD-modified surfaces improved adhesion and spreading of the osteoblast cell type.
Abstract:	Peer Reviewed
Materia(s):	-Àrees temàtiques de la UPC::Enginyeria dels materials -Osteoblasts -Biomaterials -Ossos -- Regeneració
Derechos:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Tipo de documento:	Artículo - Versión publicada Artículo
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