Título:
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Towards on line monitoring the evolution of the myocardium infarction scar with an implantable electrical impedance spectrum monitoring system.
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Autor/a:
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Bragós Bardia, Ramon; Sánchez Terrones, Benjamín; Guasch, Assumpció; Bogónez Franco, Francisco; Gálvez-Montón, C.; Puig, V.; Prat-Vidal, C.; Semino, C.E.; Bayés-Genís, Antoni
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
Abstract:
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The human heart tissue has a limited capacity for regeneration. Tissue and cellular therapies based on the use
of stem cells may be useful alternatives to limit the size of myocardial infarction. In this paper, the preliminary results from an experimental campaign for on-line monitoring of myocardium scar infarction are presented. This study has been carried out under a research project that has as main objective
the development and application of a bioactive patch implant for regeneration of myocardial infarction. Electrical Impedance
Spectroscopy (EIS) has been chosen as a tissue state monitoring technique. What is presented in this communication is the first
results of an implantable EIS measurement system which has been implanted in a subset of the animals corresponding to the control group, along one month. In all the animals, the myocardial infarction was induced by the ligation of the first circumflex marginal artery. In the animal group presented,the bioactive patch scaffold and the electrodes were implanted without the stem cells load. The scaffold is a piece of decellularized
human pericardium, lyophilized and rehydrated with hydrogel RAD16-I. Nanogold particles were also placed near the electrodes to improve the electrode area conductivity. The results presented correspond to the subset of animals (n = 5),
which had implanted the bioimpedance system monitoring the electrical impedance spectrum in vivo during 1 month. Two electrodes were connected to the bioactive patch implant. A
total of 14 logarithmically spaced frequencies were measured every 5 minutes, from 100 Hz to 200 kHz. Results show a
convergence of low-frequency and high frequency impedance magnitudes along the measurement period, which is coherent
with the scar formation. |
Materia(s):
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-Àrees temàtiques de la UPC::Ciències de la salut -Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica -Myocardial Infarction--prevention & control. -Myocardial infarction--Treatment. -Patient monitoring Equipment and supplies -Patient monitoring--Instruments -Infart de miocardi -- Tractament -Infart de miocardi -- Monitoratge de pacients -Monitoratge de pacients |
Derechos:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
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Artículo - Versión publicada Objeto de conferencia |
Editor:
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IEEE
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