dc.contributor
Universitat Ramon Llull. IQS
dc.contributor.author
Massarico Serafim, Ricardo Augusto
dc.contributor.author
Gehringer, Matthias
dc.date.accessioned
2025-09-17T11:54:32Z
dc.date.available
2025-09-17T11:54:32Z
dc.date.issued
2025-08-08
dc.identifier.issn
2575-9108
dc.identifier.uri
http://hdl.handle.net/20.500.14342/5518
dc.description.abstract
Protein kinases are highly relevant drug targets, yet a significant fraction of the human kinome remains underexplored. Highly potent and selective small-molecule inhibitors used as chemical probes are invaluable tools for enabling the validation and translation of new kinase targets. This review provides an overview and analysis of the high-quality in vivo chemical probes for protein kinases published and deposited at the Chemical Probes Portal in the year 2024. We discuss the design strategies, molecular mechanism of action, details of their use in vitro and in vivo, as well as their application in target (in)validation. We also highlight the importance of wisely selecting chemical probes and encourage best practices in using such tool compounds.
dc.publisher
American Chemical Society
dc.relation.ispartof
ACS Pharmacology & Translational Science 2025, 8 (8), 2401–2414
dc.rights
Attribution 4.0 International
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Chemical probes
dc.subject
Protein kinase inhibitors
dc.subject
Target validation
dc.subject
Drug discovery
dc.subject
Understudied kinome
dc.subject
Proteïnes quinases--Inhibidors
dc.subject
Descobriment de fàrmacs
dc.title
High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024
dc.type
info:eu-repo/semantics/article
dc.description.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
https://doi.org/10.1021/acsptsci.5c00293
dc.rights.accessLevel
info:eu-repo/semantics/openAccess
