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Title:	Accuracy of online survey assessment of mental disorders and suicidal thoughts and behaviors in spanish university students. Results of the WHO world mental health international college student initiative
Author:	Ballester, Laura; Alayo, Itxaso; Vilagut, Gemma; Almenara, José; Cebrià, Ana Isabel; Echeburúa, Enrique; Gabilondo Cuéllar, Andrea; Gili, Margalida; Lagares, Carolina; Piqueras, José Antonio; Roca, Miquel; Soto-Sanz, Victoria; Blasco, Maria Jesús; Castellví Obiols, Pere; Forero, Carlos G.; Bruffaerts, Ronny; Mortier, Philippe; Auerbach, Randy P.; Nock, Matthew K.; Sampson, Nancy; Kessler, Ronald C.; Alonso, Jordi; UNIVERSAL Study Group
Notes:	Objective: To assess the accuracy of WMH-ICS online screening scales for evaluating four common mental disorders (Major Depressive Episode[MDE], Mania/Hypomania[M/H], Panic Disorder[PD], Generalized Anxiety Disorder[GAD]) and suicidal thoughts and behaviors[STB] used in the UNIVERSAL project. Methods: Clinical diagnostic reappraisal was carried out on a subsample of the UNIVERSAL project, a longitudinal online survey of first year Spanish students (18–24 years old), part of the WHO World Mental Health-International College Student (WMH-ICS) initiative. Lifetime and 12-month prevalence of MDE, M/H, PD, GAD and STB were assessed with the Composite International Diagnostic Interview-Screening Scales [CIDI-SC], the Self-Injurious Thoughts and Behaviors Interview [SITBI] and the Columbia-Suicide Severity Rating Scale [C-SSRS]. Trained clinical psychologists, blinded to responses in the initial survey, administered via telephone the Mini-International Neuropsychiatric Interview [MINI]. Measures of diagnostic accuracy and McNemar χ2 test were calculated. Sensitivity analyses were conducted to maximize diagnostic capacity. Results: A total of 287 students were included in the clinical reappraisal study. For 12-month and lifetime mood disorders, sensitivity/specificity were 67%/88.6% and 65%/73.3%, respectively. For 12-month and lifetime anxiety disorders, these were 76.8%/86.5% and 59.6%/71.1%, and for 12-month and lifetime STB, 75.9%/94.8% and 87.2%/86.3%. For 12-month and lifetime mood disorders, anxiety disorders and STB, positive predictive values were in the range of 18.1–55.1% and negative predictive values 90.2–99.0%; likelihood ratios positive were in the range of 2.1–14.6 and likelihood ratios negative 0.1–0.6. All outcomes showed adequate areas under the curve [AUCs] (AUC>0.7), except M/H and PD (AUC = 0.6). Post hoc analyses to select optimal diagnostic thresholds led to improved concordance for all diagnoses (AUCs>0.8). Conclusion: The WMS-ICS survey showed reasonable concordance with the MINI telephone interviews performed by mental health professionals, when utilizing optimized cut-off scores. The current study provides initial evidence that the WMS-ICS survey might be useful for screening purposes.
Subject(s):	-Trastorns mentals -Depressió -Diagnòstic clínic -Salut mental -Trastornos mentales -Depresión -Diagnóstico clínico -Salud mental -Mental disorders -Depression -Clinical diagnosis -Mental health -61
Rights:	© 2019 Ballester et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/
Document type:	Article Article - Published version
Published by:	Public Library of Science
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