Sistema de Salut de Catalunya
Institut Català de la Salut
[Szczepan M, Chen M] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. [Llorián-Salvador M] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Xu H] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. Aier Institute of Optometry and Vision Science, Changsha, China
Vall d'Hebron Barcelona Hospital Campus
2023-01-10T08:30:19Z
2023-01-10T08:30:19Z
2022-06-10
Inflammation; Innate immunity; Retina
Inflamació; Immunitat innata; Retina
Inflamación; Inmunidad innata; Retina
The subretinal space is devoid of any immune cells under normal conditions and is an immune privileged site. When photoreceptors and/or retinal pigment epithelial cells suffer from an injury, a wound healing process will be initiated. Retinal microglia and the complement system, as the first line of retinal defense, are activated to participate in the wound healing process. If the injury is severe or persists for a prolonged period, they may fail to heal the damage and circulating immune cells will be summoned leading to chronic inflammation and abnormal wound healing, i.e., subretinal or intraretinal fibrosis, a sight-threatening condition frequently observed in rhematogenous retinal detachment, age-related macular degeneration and recurrent uveoretinitis. Here, we discussed the principles of subretinal wound healing with a strong focus on the conditions whereby the damage is beyond the healing capacity of the retinal defense system and highlighted the roles of circulating immune cells in subretinal wound healing and fibrosis.
This work was supported by Fight for Sight (5057/5058, 5105/5106) and Medical Research Council (United Kingdom)(MR/W004681/1).
Article
Published version
English
Retina - Patogènesi; Degeneració macular; Immunitat cel·lular; DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis; ANATOMY::Sense Organs::Eye::Retina; Other subheadings::Other subheadings::Other subheadings::/pathology; DISEASES::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration; PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular; ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis; ANATOMÍA::órganos de los sentidos::ojo::retina; Otros calificadores::Otros calificadores::Otros calificadores::/patología; ENFERMEDADES::oftalmopatías::enfermedades de la retina::degeneración retiniana::degeneración macular; FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad adaptativa::inmunidad celular
Frontiers Media
Frontiers in Cellular Neuroscience;16
https://doi.org/10.3389/fncel.2022.916719
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - VHIR [1655]
