dc.contributor
Institut Català de la Salut
dc.contributor
[Szczepan M, Chen M] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. [Llorián-Salvador M] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Xu H] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. Aier Institute of Optometry and Vision Science, Changsha, China
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Szczepan, Manon
dc.contributor.author
Llorian Salvador, Maria
dc.contributor.author
Chen, Mei
dc.contributor.author
Xu, Heping
dc.date.accessioned
2025-10-24T08:55:24Z
dc.date.available
2025-10-24T08:55:24Z
dc.date.issued
2023-01-10T08:30:19Z
dc.date.issued
2023-01-10T08:30:19Z
dc.date.issued
2022-06-10
dc.identifier
Szczepan M, Llorián-Salvador M, Chen M, Xu H. Immune Cells in Subretinal Wound Healing and Fibrosis. Front Cell Neurosci. 2022 Jun 10;16:916719.
dc.identifier
https://hdl.handle.net/11351/8797
dc.identifier
10.3389/fncel.2022.916719
dc.identifier
000815686200001
dc.identifier.uri
http://hdl.handle.net/11351/8797
dc.description.abstract
Inflammation; Innate immunity; Retina
dc.description.abstract
Inflamació; Immunitat innata; Retina
dc.description.abstract
Inflamación; Inmunidad innata; Retina
dc.description.abstract
The subretinal space is devoid of any immune cells under normal conditions and is an immune privileged site. When photoreceptors and/or retinal pigment epithelial cells suffer from an injury, a wound healing process will be initiated. Retinal microglia and the complement system, as the first line of retinal defense, are activated to participate in the wound healing process. If the injury is severe or persists for a prolonged period, they may fail to heal the damage and circulating immune cells will be summoned leading to chronic inflammation and abnormal wound healing, i.e., subretinal or intraretinal fibrosis, a sight-threatening condition frequently observed in rhematogenous retinal detachment, age-related macular degeneration and recurrent uveoretinitis. Here, we discussed the principles of subretinal wound healing with a strong focus on the conditions whereby the damage is beyond the healing capacity of the retinal defense system and highlighted the roles of circulating immune cells in subretinal wound healing and fibrosis.
dc.description.abstract
This work was supported by Fight for Sight (5057/5058, 5105/5106) and Medical Research Council (United Kingdom)(MR/W004681/1).
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Cellular Neuroscience;16
dc.relation
https://doi.org/10.3389/fncel.2022.916719
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Retina - Patogènesi
dc.subject
Degeneració macular
dc.subject
Immunitat cel·lular
dc.subject
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis
dc.subject
ANATOMY::Sense Organs::Eye::Retina
dc.subject
Other subheadings::Other subheadings::Other subheadings::/pathology
dc.subject
DISEASES::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration
dc.subject
PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular
dc.subject
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis
dc.subject
ANATOMÍA::órganos de los sentidos::ojo::retina
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/patología
dc.subject
ENFERMEDADES::oftalmopatías::enfermedades de la retina::degeneración retiniana::degeneración macular
dc.subject
FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad adaptativa::inmunidad celular
dc.title
Immune Cells in Subretinal Wound Healing and Fibrosis
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
