Sistema de Salut de Catalunya
Institut Català de la Salut
[Altena R] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Breast cancer, Endocrine tumors and Sarcoma, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden. [Bajalica-Lagercrantz S] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden. [Papakonstantinou A] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Breast cancer, Endocrine tumors and Sarcoma, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden. Breast Cancer Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2022-10-26T12:20:00Z
2022-10-26T12:20:00Z
2022-09-25
Breast cancer; Cardiotoxicity; Pharmacogenomics
Cáncer de mama; Cardiotoxicidad; Farmacogenómica
Càncer de mama; Cardiotoxicitat; Farmacogenòmica
Pharmacogenomics is an emerging field in oncology, one that could provide valuable input on identifying patients with inherent risk of toxicity, thus allowing for treatment tailoring and personalization on the basis of the clinical and genetic characteristics of a patient. Cardiotoxicity is a well-known side effect of anthracyclines and anti-HER2 agents, although at a much lower incidence for the latter. Data on single-nucleotide polymorphisms related to cardiotoxicity are emerging but are still scarce, mostly being of retrospective character and heterogeneous. A literature review was performed, aiming to describe current knowledge in pharmacogenomics and prediction of cardiotoxicity related to breast cancer systemic therapies and radiotherapies. Most available data regard genes encoding various enzymes related to anthracycline metabolism and HER2 polymorphisms. The available data are presented, together with the challenges and open questions in the field.
This study was supported by a grant from Percy Falks Stiftelse to A.P.
Article
Published version
English
Mama - Càncer - Tractament; Farmacogenòmica; Toxicologia cardiovascular; DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Pharmacogenetics; DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms; Other subheadings::Other subheadings::Other subheadings::/drug therapy; DISEASES::Chemically-Induced Disorders::Drug-Related Side Effects and Adverse Reactions::Cardiotoxicity; DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::genética::farmacogenética; ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; ENFERMEDADES::trastornos inducidos químicamente::efectos colaterales y reacciones adversas relacionados con medicamentos::cardiotoxicidad
MDPI
Cancers;14(19)
https://doi.org/10.3390/cancers14194665
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
