dc.contributor
Institut Català de la Salut
dc.contributor
[Andrade F] Grup d'Orientació i Distribució de Medicaments, Recerca en Biologia Molecular i Bioquímica, Centre de Nanomedicina (CIBBIM-Nanomedicina), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Roca-Melendres MM] Grup d'Orientació i Distribució de Medicaments, Recerca en Biologia Molecular i Bioquímica, Centre de Nanomedicina (CIBBIM-Nanomedicina), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Durán-Lara EF] Bio and NanoMaterials Lab, Drug Delivery and Controlled Release, Universidad de Talca, Talca 3460000, Maule, Chile. Departamento de Microbiología, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Maule, Chile. [Rafael D, Schwartz S Jr] Grup d'Orientació i Distribució de Medicaments, Recerca en Biologia Molecular i Bioquímica, Centre de Nanomedicina (CIBBIM-Nanomedicina), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Andrade, Fernanda
dc.contributor.author
Roca-Melendres, Maria Mercè
dc.contributor.author
Durán-Lara, Esteban F.
dc.contributor.author
Schwartz Navarro, Simon
dc.contributor.author
Rafael, Diana
dc.date.accessioned
2025-10-24T08:48:18Z
dc.date.available
2025-10-24T08:48:18Z
dc.date.issued
2022-03-30T09:27:19Z
dc.date.issued
2022-03-30T09:27:19Z
dc.identifier
Andrade F, Roca-Melendres MM, Durán-Lara EF, Rafael D, Schwartz S. Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field. Cancers. 2021 Mar;13(5):1164.
dc.identifier
https://hdl.handle.net/11351/7276
dc.identifier
10.3390/cancers13051164
dc.identifier
000627971800001
dc.identifier.uri
http://hdl.handle.net/11351/7276
dc.description.abstract
Tractament contra el càncer; Hidrogels; Fotosensible
dc.description.abstract
Tratamiento contra el cancer; Hidrogeles; Fotosensible
dc.description.abstract
Cancer treatment; Hydrogels; Photosensitive
dc.description.abstract
Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to systemic high doses of chemotherapy and the development of drug resistance impairs a safe and efficiency anticancer therapy. Therefore, new formulations are continuously under research and development to improve anticancer drugs therapeutic index through localized delivery at tumor sites. Among a wide range of possibilities, hydrogels have recently gained special attention due to their potential to allow in situ sustained and controlled anticancer drug release. In particular, stimuli-responsive hydrogels which are able to change their physical state from liquid to gel accordingly to external factors such as temperature, pH, light, ionic strength, and magnetic field, among others. Some of these formulations presented promising results for the localized control and treatment of cancer. The present work aims to discuss the main properties and application of stimuli-responsive hydrogels in cancer treatment and summarize the most important advances observed in the last decades focusing on the use of pH-, light-, ionic strength-, and magnetic-responsive hydrogels.
dc.description.abstract
This work was supported by ANID FONDECYT REGULAR (Chile) through project Nº 1210476 from Esteban F. Durán-Lara.
dc.format
application/pdf
dc.relation
Cancers;13(5)
dc.relation
https://doi.org/10.3390/cancers13051164
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Càncer - Tractament
dc.subject
Col·loides - Ús terapèutic
dc.subject
Medicaments - Modes d'administració
dc.subject
CHEMICALS AND DRUGS::Pharmaceutical Preparations::Dosage Forms::Colloids::Gels::Hydrogels
dc.subject
Other subheadings::Other subheadings::/chemistry
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Drug Delivery Systems
dc.subject
DISEASES::Neoplasms
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::preparados farmacéuticos::formas farmacéuticas::coloides::geles::hidrogeles
dc.subject
Otros calificadores::Otros calificadores::/química
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::sistemas de liberación de medicamentos
dc.subject
ENFERMEDADES::neoplasias
dc.title
Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
