Sistema de Salut de Catalunya
Institut Català de la Salut
[Andrade F] Grup d'Orientació i Distribució de Medicaments, Recerca en Biologia Molecular i Bioquímica, Centre de Nanomedicina (CIBBIM-Nanomedicina), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Roca-Melendres MM] Grup d'Orientació i Distribució de Medicaments, Recerca en Biologia Molecular i Bioquímica, Centre de Nanomedicina (CIBBIM-Nanomedicina), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Durán-Lara EF] Bio and NanoMaterials Lab, Drug Delivery and Controlled Release, Universidad de Talca, Talca 3460000, Maule, Chile. Departamento de Microbiología, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Maule, Chile. [Rafael D, Schwartz S Jr] Grup d'Orientació i Distribució de Medicaments, Recerca en Biologia Molecular i Bioquímica, Centre de Nanomedicina (CIBBIM-Nanomedicina), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
2022-03-30T09:27:19Z
2022-03-30T09:27:19Z
2021-03
Tractament contra el càncer; Hidrogels; Fotosensible
Tratamiento contra el cancer; Hidrogeles; Fotosensible
Cancer treatment; Hydrogels; Photosensitive
Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to systemic high doses of chemotherapy and the development of drug resistance impairs a safe and efficiency anticancer therapy. Therefore, new formulations are continuously under research and development to improve anticancer drugs therapeutic index through localized delivery at tumor sites. Among a wide range of possibilities, hydrogels have recently gained special attention due to their potential to allow in situ sustained and controlled anticancer drug release. In particular, stimuli-responsive hydrogels which are able to change their physical state from liquid to gel accordingly to external factors such as temperature, pH, light, ionic strength, and magnetic field, among others. Some of these formulations presented promising results for the localized control and treatment of cancer. The present work aims to discuss the main properties and application of stimuli-responsive hydrogels in cancer treatment and summarize the most important advances observed in the last decades focusing on the use of pH-, light-, ionic strength-, and magnetic-responsive hydrogels.
This work was supported by ANID FONDECYT REGULAR (Chile) through project Nº 1210476 from Esteban F. Durán-Lara.
Artículo
Versión publicada
Inglés
Càncer - Tractament; Col·loides - Ús terapèutic; Medicaments - Modes d'administració; CHEMICALS AND DRUGS::Pharmaceutical Preparations::Dosage Forms::Colloids::Gels::Hydrogels; Other subheadings::Other subheadings::/chemistry; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Drug Delivery Systems; DISEASES::Neoplasms; COMPUESTOS QUÍMICOS Y DROGAS::preparados farmacéuticos::formas farmacéuticas::coloides::geles::hidrogeles; Otros calificadores::Otros calificadores::/química; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::sistemas de liberación de medicamentos; ENFERMEDADES::neoplasias
MDPI
Cancers;13(5)
https://doi.org/10.3390/cancers13051164
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - VHIR [1655]
