Sistema de Salut de Catalunya
Institut Català de la Salut
[Olaso-Gonzalez G, Viña J] Department of Physiology, Faculty of Medicine, Universitat de València, Valencia, Spain. [Inzitari M] REFiT Barcelona Research Group, Parc Sanitari Pere Virgili, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Department of Health Sciences, Universitat Oberta de Catalonia, Barcelona, Spain. [Bellelli G] School of Medicine and Surgery, University of Milano-Bicocca and Acute Geriatric Unit, San Gerardo Hospital, Monza, Italy. [Morandi A] REFiT Barcelona Research Group, Parc Sanitari Pere Virgili, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Department of Rehabilitation and Aged Care, Fondazione Teresa Camplani, Hospital Ancelle, Cremona, Italy. [Barcons N] Medical Affairs, Nestlé Health Science, Vevey, Switzerland
Vall d'Hebron Barcelona Hospital Campus
2022-02-25T13:44:30Z
2022-02-25T13:44:30Z
2021
2022-01
Àcid fòlic; Hhomocisteïna; Deteriorament cognitiu lleu
Ácido fólico; Homocisteína; Deterioro cognitivo leve
Folic acid; Homocysteine; Mild cognitive impairment
Hyperhomocysteinemia is an independent predictor of the risk for cognitive decline and may be a result of low levels of vitamins B12, B6, and folate. Previous findings suggest that adequate intake of these vitamins may reduce homocysteine levels. This review aimed to assess the effects of treatment with vitamins B6, B12, and/or folic acid in the homocysteine levels in patients with mild cognitive impairment (MCI). A systematic literature review was conducted in EMBASE, MEDLINE®, PsycINFO, and Cochrane Central Register of Controlled Trials. The research question was formulated using the Population, Intervention, Comparison, and Outcome (PICO) framework: in patients with MCI (P); what is the efficacy of vitamins B6, B12, and/or folic acid intake (I); compared with baseline values, and/or compared with controls (C); in reducing homocysteine levels from baseline (O). A total of eight primary studies with a total of 1,140 participants were included in the review. Four were randomized controlled trials, one was a quasi-controlled trial, and three were observational studies. All studies included folic acid in their intervention, seven vitamin B12, and four vitamin B6. Mean (SD) length of the intervention period was 18.8 (19.3) months, ranging from 1 to 60 months. All studies showed a statistically significant decrease in homocysteine levels in groups treated with vitamins B6, B12, and/or folic acid compared to controls, with a mean decline of homocysteine concentration of 31.9% in the intervention arms whereas it increased by 0.7% in the control arm. This review identified evidence of a reduction of plasma homocysteine levels in MCI patients taking vitamins B6, B12, and/or folic acid supplements, with statistically significant declines being observed after 1 month of supplementation. Findings support that supplementation with these vitamins might be an option to reduce homocysteine levels in people with MCI and elevated plasma homocysteine.
Nestlé Health Science, Switzerland
Article
Versió publicada
Anglès
Trastorns de la cognició - Tractament; Vitamines B - Ús terapèutic; Avaluació de resultats (Assistència sanitària); PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders::Cognitive Dysfunction; CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Nutrients::Micronutrients::Vitamins; Other subheadings::Other subheadings::/therapeutic use; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome; PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos::disfunción cognitiva; COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias del crecimiento::nutrientes::micronutrientes::vitaminas; Otros calificadores::Otros calificadores::/uso terapéutico; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
Wiley
IUBMB Life;74(1)
https://doi.org/10.1002/iub.2507
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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