Sistema de Salut de Catalunya
Institut Català de la Salut
[Borges FK] Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada. [Bhandari M, Avram V] Department of Surgery, McMaster University, Hamilton, Ontario, Canada. [Patel A] Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [Guerra-Farfán E, Teixidor-Serra J, Tomas-Hernandez J] Servei de Cirurgia Ortopèdica i Traumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sigamani A] Department of Clinical Research, Narayana Health, Bangalore, India.
Vall d'Hebron Barcelona Hospital Campus
2019-06-25T10:49:31Z
2019-06-25T10:49:31Z
2019-05-01
Accelerated surgery; Hip fracture; Randomised control trial
Cirurgia accelerada; Fractura de maluc; Prova controlada aleatòria
Cirugía acelerada; Fractura de cadera; Prueba controlada aleatorizada
INTRODUCTION: Annually, millions of adults suffer hip fractures. The mortality rate post a hip fracture is 7%-10% at 30 days and 10%-20% at 90 days. Observational data suggest that early surgery can improve these outcomes in hip fracture patients. We designed a clinical trial-HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) to determine the effect of accelerated surgery compared with standard care on the 90-day risk of all-cause mortality and major perioperative complications. METHODS AND ANALYSIS: HIP ATTACK is a multicentre, international, parallel group randomised controlled trial (RCT) that will include patients ≥45 years of age and diagnosed with a hip fracture from a low-energy mechanism requiring surgery. Patients are randomised to accelerated medical assessment and surgical repair (goal within 6 h) or standard care. The co-primary outcomes are (1) all-cause mortality and (2) a composite of major perioperative complications (ie, mortality and non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding) at 90 days after randomisation. All patients will be followed up for a period of 1 year. We will enrol 3000 patients. ETHICS AND DISSEMINATION: All centres had ethics approval before randomising patients. Written informed consent is required for all patients before randomisation. HIP ATTACK is the first large international trial designed to examine whether accelerated surgery can improve outcomes in patients with a hip fracture. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organisations, and providing public awareness through multimedia resources. TRIAL REGISTRATION NUMBER: NCT02027896; Pre-results.
Article
Published version
English
Articulació coxofemoral - Cirurgia; Assaigs clínics; DISEASES::Wounds and Injuries::Fractures, Bone::Femoral Fractures::Hip Fractures; Other subheadings::Other subheadings::Other subheadings::/surgery; HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Early Medical Intervention; HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics::Clinical Protocols::Clinical Trial Protocols as Topic; ENFERMEDADES::heridas y lesiones::fracturas óseas::fracturas del fémur::fracturas de cadera; Otros calificadores::Otros calificadores::Otros calificadores::/cirugía; ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::servicios de salud::servicios preventivos de salud::intervención médica temprana; ATENCIÓN DE SALUD::calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::mecanismos de evaluación de la atención sanitaria::características de los estudios epidemiológicos::protocolos clínicos::protocolos de ensayos clínicos como asunto
BMJ Publishing Group
BMJ Open;9(4)
https://bmjopen.bmj.com/content/9/4/e028537
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Articles científics - HVH [3440]
