dc.contributor
Institut Català de la Salut
dc.contributor
[O’Regan P, Butt F] Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom. [Carter L, Graham DM] Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. The Christie NHS Foundation Trust, Manchester, United Kingdom. [Le Blanc A, Hoskins R] Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom. Research IT, The University of Manchester, Manchester, United Kingdom. [Pretelli G, Garralda E] Unitat de Desenvolupament de Fàrmacs en Fase Inicial, Vall d’Hebron Institut d'Oncologia (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
O'Regan, Paul
dc.contributor.author
Butt, Fouziah
dc.contributor.author
Carter, Louise
dc.contributor.author
Graham, Donna M.
dc.contributor.author
Le Blanc, Anja
dc.contributor.author
Hoskins, Richard
dc.contributor.author
Pretelli, Giulia
dc.contributor.author
GARRALDA, Elena
dc.date.accessioned
2026-03-26T20:50:02Z
dc.date.available
2026-03-26T20:50:02Z
dc.date.issued
2026-03-25T09:00:57Z
dc.date.issued
2026-03-25T09:00:57Z
dc.date.issued
2025-11-27
dc.identifier
O’Regan P, Butt F, Carter L, Graham DM, Le Blanc A, Hoskins R, et al. UpSMART: five years of digital innovation in cancer clinical research—achievements, challenges, and recommendations. Front Digit Heal. 2025 Nov 27;7:1708067.
dc.identifier
http://hdl.handle.net/11351/14389
dc.identifier
doi.org/10.3389/fdgth.2025.1708067
dc.identifier
001635590200001
dc.identifier.uri
https://hdl.handle.net/11351/14389
dc.description.abstract
Cancer clinical trials; Clinical trial innovation; Digital health technologies
dc.description.abstract
Ensayos clínicos oncológicos; Innovación en ensayos clínicos; Tecnologías de salud digital
dc.description.abstract
Assaigs clínics oncològics; Innovació en assaigs clínics; Tecnologies de salut digital
dc.description.abstract
UpSMART, a research programme involving 24 European cancer centres, aimed to promote digital innovation in early-phase clinical research addressing challenges in recruitment, data collection and analysis. Several open-source digital healthcare products (DHPs) were developed through UpSMART, including eTARGET and trialFinder for trial matching, and PROACT 2.0 for patient-reported data. Lessons learned highlight the importance of multidisciplinary teams, sustainable funding and deployment, and engagement with the research community to maximise impact.
dc.description.abstract
The author(s) declare financial support was received for the research and/or publication of this article. This work was supported by Cancer Research UK (CRUK), Associazione Italiana per la Ricerca sul Cancro (AIRC) and Fundacion Científica-Asociacion Espanola Contra el Cancer (FC-AECC), via an Accelerator Award [A29374] through the CRUK National Biomarker Centre [CTRNBC-2022/100001]. This work was supported by Azure sponsorship credits granted by Microsoft’s AI for Good Research Lab. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Digital Health;7
dc.relation
https://doi.org/10.3389/fdgth.2025.1708067
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Assaigs clínics
dc.subject
Històries clíniques - Informàtica
dc.subject
Medicina - Innovacions
dc.subject
INFORMATION SCIENCE::Information Science::Computing Methodologies::Software
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Clinical Studies as Topic::Clinical Trials as Topic
dc.subject
DISCIPLINES AND OCCUPATIONS::Health Occupations::Medicine::Internal Medicine::Medical Oncology
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Records::Medical Records::Medical Records Systems, Computerized::Electronic Health Records
dc.subject
CIENCIA DE LA INFORMACIÓN::Ciencias de la información::metodologías computacionales::soporte lógico (informática)
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios clínicos como asunto::ensayos clínicos como asunto
dc.subject
DISCIPLINAS Y OCUPACIONES::profesiones sanitarias::medicina::medicina interna::oncología médica
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::registros::registros médicos::sistemas informatizados de historias clínicas
dc.title
UpSMART: five years of digital innovation in cancer clinical research—achievements, challenges, and recommendations
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
