Chronic myelomonocytic leukemia with NPM1 mutation or acute myeloid leukemia?

Altres autors/es

[Castaño-Díez S] Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Universitat Barcelona, Barcelona, Spain. [Álamo JR, Gómez-Hernando M] Hematopathology Section, Pathology Department, Hospital Clínic Barcelona, Barcelona, Spain. [López-Guerra M] Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Hematopathology Section, Pathology Department, Hospital Clínic Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. [Zugasti I, Jiménez-Vicente C] Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain. [Vela D] Hematology Department, Hospital General de Granollers, Granollers, Spain

Hospital General de Granollers

Data de publicació

2026-02-10T11:40:27Z

2026-02-10T11:40:27Z

2025-02-06



Resum

Acute myeloid leukemia; Chronic myelomonocytic leukemia; ICC classification


Leucèmia mieloide aguda; Leucèmia mielomonocítica crònica; Classificació de la CCI


Leucemia mieloide aguda; Leucemia mielomonocítica crónica; Clasificación ICC


The 2022 WHO revision and the ICC classification have recently modified the diagnostic criteria for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia. However, there is no consensus on whether CMML with NPM1 mutation (NPM1mut) should be diagnosed as AML. Nowadays, it is a subject of discussion because of its diagnostic and therapeutic implications. Therefore, we describe a case of a patient diagnosed with CMML NPM1mut and briefly review the literature to highlight the uncertainty about how to classify a CMML with NPM1 mutation. We emphasize the importance of a comprehensive molecular study, which is crucial to optimize the individualized treatment of patients, enabling them to access targeted therapies.

Tipus de document

Article


Versió publicada

Llengua

Anglès

Publicat per

Oxford University Press

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Attribution 4.0 International

http://creativecommons.org/licenses/by/4.0/

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