dc.contributor
Institut Català de la Salut
dc.contributor
[de Vries ISA] Princess Máxima Center for Pediatric Oncology, CS Utrecht, Netherlands. [Morosi C] Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [Bisogno G] Department of Women’s and Children’s Health, University of Padua, Padua, Italy. Pediatric Hematology Oncology Division, University Hospital of Padua, Padua, Italy. [Minard Colin V] Department of Pediatric and Adolescent Oncology, Gustave-Roussy, Université Paris-Saclay, Villejuif, France. [Coppadoro B] Department of Women’s and Children’s Health, University of Padua, Padua, Italy. [Zanetti I] Pediatric Hematology Oncology Division, University Hospital of Padua, Padua, Italy. [Guillen G] Servei de Cirurgia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
de Vries, Isabelle S. A.
dc.contributor.author
Zanetti, Ilaria
dc.contributor.author
Morosi, Carlo
dc.contributor.author
Bisogno, Gianni
dc.contributor.author
Minard-Colin, Veronique
dc.contributor.author
Coppadoro, Beatrice
dc.contributor.author
Guillén Burrieza, Gabriela
dc.date.accessioned
2025-11-01T20:11:03Z
dc.date.available
2025-11-01T20:11:03Z
dc.date.issued
2025-10-31T07:25:50Z
dc.date.issued
2025-10-31T07:25:50Z
dc.identifier
de Vries ISA, Morosi C, Bisogno G, Minard-Colin V, Coppadoro B, Zanetti I, et al. Early radiologic tumour volume response in non-metastatic rhabdomyosarcoma is not predictive for survival. Pediatr Radiol. 2025 Sep;55:2160–70.
dc.identifier
http://hdl.handle.net/11351/13989
dc.identifier
10.1007/s00247-025-06359-3
dc.identifier
001551367000001
dc.identifier.uri
http://hdl.handle.net/11351/13989
dc.description.abstract
Paediatric oncology; Radiological response assessment; Rhabdomyosarcoma
dc.description.abstract
Oncología pediátrica; Evaluación de la respuesta radiológica; Rabdomiosarcoma
dc.description.abstract
Oncologia pediàtrica; Avaluació de la resposta radiològica; Rabdomiosarcoma
dc.description.abstract
Background
There is an urgent need for early radiological markers predicting survival in paediatric rhabdomyosarcoma patients.
Objective
To analyse the predictive value of early radiological tumour volume response to chemotherapy in non-metastatic rhabdomyosarcoma patients.
Methods
The European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS 2005 study prospectively included non-metastatic rhabdomyosarcoma patients. Patients with Intergroup Rhabdomyosarcoma Studies (IRS) postsurgical Group III (i.e. measurable disease) at diagnosis, with three tumour diameters available at diagnosis and following three cycles of chemotherapy, were included. Tumour response was categorized as complete response, partial response, minor partial response, stable disease, or progressive disease. Patients with progressive disease were excluded from analyses. Failure-free survival and overall survival were estimated with Kaplan-Meier using a landmark analysis. Prognostic factors were assessed using Cox proportional hazards analyses.
Results
Of 1,674 patients aged < 18 years at diagnosis included in the EpSSG RMS 2005 study, 613 patients (median age 4.2 years, interquartile range 2.2–8.0, 346 males) were eligible for analysis. After three cycles of chemotherapy, 48 patients reached complete response, 371 partial response, 139 minor partial response, 48 stable disease, and seven patients progressive disease. Univariate Cox proportional hazards model showed no significant difference between response groups for failure-free survival or overall survival. In multivariate Cox regression analysis, tumour volume response was not an independent prognostic factor for failure-free survival or overall survival.
Conclusion
Early radiological tumour volume response after the third cycle of neoadjuvant chemotherapy, with exclusion of progressive disease, does not predict survival in paediatric rhabdomyosarcoma patients.
dc.description.abstract
Alice's Arc, a children’s cancer charity focusing on rhabdomyosarcoma, United Kingdom (alicesarc.org), has funded data management and statistical processing for current analyses.
dc.format
application/pdf
dc.relation
Pediatric Radiology;55
dc.relation
https://doi.org/10.1007/s00247-025-06359-3
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Tumors de parts toves - Quimioteràpia
dc.subject
Tumors de parts toves - Radioteràpia
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Tumors de parts toves - Prognosi
dc.subject
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Muscle Tissue::Myosarcoma::Rhabdomyosarcoma
dc.subject
Other subheadings::Other subheadings::Other subheadings::/drug therapy
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Anthropometry::Body Weights and Measures::Tumor Burden
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
dc.subject
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido muscular::miosarcoma::rabdomiosarcoma
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::antropometría::pesos y medidas corporales::carga tumoral
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
dc.title
Early radiologic tumour volume response in non-metastatic rhabdomyosarcoma is not predictive for survival
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
