dc.contributor
Institut Català de la Salut
dc.contributor
[Cros J] Department of Pathology, Beaujon Hospital (AP-HP), Université Paris Cité, Paris, France. [Casanovas O] ProCURE, Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain. [Castaño JP] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. Reina Sofia University Hospital, Córdoba, Spain. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. [Dayton T] Tissue Biology and Disease Modelling, European Molecular Biology Laboratory (EMBL) Barcelona, Barcelona, Spain. [Garcia Alvarez A] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Gastrointestinal and Endocrine Tumor Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Gibert B] Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Cros, Jerome
dc.contributor.author
Casanovas, Oriol
dc.contributor.author
Castaño, Justo P.
dc.contributor.author
Dayton, Talya
dc.contributor.author
GIBERT, Benjamin
dc.contributor.author
Garcia-Alvarez, Alejandro
dc.date.accessioned
2025-10-30T15:24:01Z
dc.date.available
2025-10-30T15:24:01Z
dc.date.issued
2025-10-29T08:00:30Z
dc.date.issued
2025-10-29T08:00:30Z
dc.identifier
Cros J, Casanovas O, Castaño JP, Dayton T, Alvarez AG, Gibert B, et al. White paper on best practices for translational research in neuroendocrine neoplasms. J Neuroendocrinol. 2025 Oct;37(10):e70072.
dc.identifier
http://hdl.handle.net/11351/13944
dc.identifier
10.1111/jne.70072
dc.identifier
001538248900001
dc.identifier.uri
http://hdl.handle.net/11351/13944
dc.description.abstract
Carcinoids; Genomics; Liquid biopsy
dc.description.abstract
Carcinoides; Genómica; Biopsia líquida
dc.description.abstract
Carcinoides; Genòmica; Biòpsia líquida
dc.description.abstract
Basic and translational investigations play a crucial role in advancing our understanding of neuroendocrine neoplasms (NENs). In this white paper by the Basic and Translational Research Group of the European Neuroendocrine Tumor Society, we discuss the qualities and drawbacks of current disease models and propose good practices for integrating state-of-the-art technologies including bulk and single-cell genomics, transcriptomics, and proteomics in contemporary NEN research. We also provide insights on how to properly handle tissue samples (particularly when starting material is limited) and discuss technical hints of relevance when planning liquid biopsy or tumor immunology studies. Future translational studies of NENs will benefit from centralized biologic material biobanking, research design planning in the context of multi-expertise committees, as well as experimental protocol optimization and sharing across the NEN scientific community.
dc.format
application/pdf
dc.relation
Journal of Neuroendocrinology;37(10)
dc.relation
https://doi.org/10.1111/jne.70072
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Tumors neuroendocrins
dc.subject
Medicina - Investigació
dc.subject
DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Science::Research::Biomedical Research::Translational Medical Research
dc.subject
DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Proteomics
dc.subject
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors
dc.subject
DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::ciencia::investigación::investigación biomédica::investigación médica traslacional
dc.subject
DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::bioquímica::proteómica
dc.subject
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos
dc.title
White paper on best practices for translational research in neuroendocrine neoplasms
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
