Sistema de Salut de Catalunya
Institut Català de la Salut
[Cros J] Department of Pathology, Beaujon Hospital (AP-HP), Université Paris Cité, Paris, France. [Casanovas O] ProCURE, Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain. [Castaño JP] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. Reina Sofia University Hospital, Córdoba, Spain. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. [Dayton T] Tissue Biology and Disease Modelling, European Molecular Biology Laboratory (EMBL) Barcelona, Barcelona, Spain. [Garcia Alvarez A] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Gastrointestinal and Endocrine Tumor Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Gibert B] Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
Vall d'Hebron Barcelona Hospital Campus
2025-10-29T08:00:30Z
2025-10-29T08:00:30Z
2025-10
Carcinoids; Genomics; Liquid biopsy
Carcinoides; Genómica; Biopsia líquida
Carcinoides; Genòmica; Biòpsia líquida
Basic and translational investigations play a crucial role in advancing our understanding of neuroendocrine neoplasms (NENs). In this white paper by the Basic and Translational Research Group of the European Neuroendocrine Tumor Society, we discuss the qualities and drawbacks of current disease models and propose good practices for integrating state-of-the-art technologies including bulk and single-cell genomics, transcriptomics, and proteomics in contemporary NEN research. We also provide insights on how to properly handle tissue samples (particularly when starting material is limited) and discuss technical hints of relevance when planning liquid biopsy or tumor immunology studies. Future translational studies of NENs will benefit from centralized biologic material biobanking, research design planning in the context of multi-expertise committees, as well as experimental protocol optimization and sharing across the NEN scientific community.
Article
Published version
English
Tumors neuroendocrins; Proteòmica; Medicina - Investigació; DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Science::Research::Biomedical Research::Translational Medical Research; DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Proteomics; DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors; DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::ciencia::investigación::investigación biomédica::investigación médica traslacional; DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::bioquímica::proteómica; ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos
Wiley
Journal of Neuroendocrinology;37(10)
https://doi.org/10.1111/jne.70072
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3393]
