dc.contributor
Institut Català de la Salut
dc.contributor
[Martínez-Jiménez F] Systems Oncology Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Hartwig Medical Foundation, Amsterdam, The Netherlands. [Chowell D] The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Chowell, Diego
dc.contributor.author
Martínez-Jiménez, Francisco
dc.date.accessioned
2025-10-25T05:38:17Z
dc.date.available
2025-10-25T05:38:17Z
dc.date.issued
2025-04-22T07:53:37Z
dc.date.issued
2025-04-22T07:53:37Z
dc.identifier
Martínez-Jiménez F, Chowell D. Genetic immune escape in cancer: timing and implications for treatment. Trends in Cancer. 2025 Apr;11(4):286–94.
dc.identifier
http://hdl.handle.net/11351/12971
dc.identifier
10.1016/j.trecan.2024.11.002
dc.identifier.uri
http://hdl.handle.net/11351/12971
dc.description.abstract
Immunotherapy resistance; Tumor evolution; Tumor microenvironment
dc.description.abstract
Resistencia a la inmunoterapia; Evolución del tumor; Microambiente tumoral
dc.description.abstract
Resistència a la immunoteràpia; Evolució del tumor; Microambient tumoral
dc.description.abstract
Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which can vary significantly across cancer types, may often arise early in clonal evolution and contribute to malignant transformation. As tumors evolve, GIE alterations are positively selected, allowing immune-resistant clones to proliferate. In addition to genetic changes, the tumor microenvironment (TME) and non-genetic factors such as inflammation, smoking, and environmental exposures play crucial roles in promoting immune evasion. Understanding the timing and mechanisms of GIE, alongside microenvironmental influences, is crucial for improving early detection and developing more effective therapeutic interventions. This review highlights the implications of GIE in cancer development and immunotherapy resistance, and emphasizes the need for integrative approaches.
dc.format
application/pdf
dc.relation
Trends in Cancer;11(4)
dc.relation
https://doi.org/10.1016/j.trecan.2024.11.002
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Càncer - Immunoteràpia
dc.subject
Càncer - Aspectes genètics
dc.subject
Resistència als medicaments
dc.subject
DISEASES::Neoplasms
dc.subject
Other subheadings::Other subheadings::/therapy
dc.subject
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
dc.subject
PHENOMENA AND PROCESSES::Immune System Phenomena::Tumor Escape
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
dc.subject
ENFERMEDADES::neoplasias
dc.subject
Otros calificadores::Otros calificadores::/terapia
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos
dc.subject
FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::escape del tumor
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
dc.title
Genetic immune escape in cancer: timing and implications for treatment
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
