Sistema de Salut de Catalunya
Institut Català de la Salut
[Martínez-Jiménez F] Systems Oncology Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Hartwig Medical Foundation, Amsterdam, The Netherlands. [Chowell D] The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Vall d'Hebron Barcelona Hospital Campus
2025-04-22T07:53:37Z
2025-04-22T07:53:37Z
2024
2025-04
Immunotherapy resistance; Tumor evolution; Tumor microenvironment
Resistencia a la inmunoterapia; Evolución del tumor; Microambiente tumoral
Resistència a la immunoteràpia; Evolució del tumor; Microambient tumoral
Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which can vary significantly across cancer types, may often arise early in clonal evolution and contribute to malignant transformation. As tumors evolve, GIE alterations are positively selected, allowing immune-resistant clones to proliferate. In addition to genetic changes, the tumor microenvironment (TME) and non-genetic factors such as inflammation, smoking, and environmental exposures play crucial roles in promoting immune evasion. Understanding the timing and mechanisms of GIE, alongside microenvironmental influences, is crucial for improving early detection and developing more effective therapeutic interventions. This review highlights the implications of GIE in cancer development and immunotherapy resistance, and emphasizes the need for integrative approaches.
Article
Published version
English
Càncer - Immunoteràpia; Càncer - Aspectes genètics; Resistència als medicaments; DISEASES::Neoplasms; Other subheadings::Other subheadings::/therapy; PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm; PHENOMENA AND PROCESSES::Immune System Phenomena::Tumor Escape; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy; ENFERMEDADES::neoplasias; Otros calificadores::Otros calificadores::/terapia; FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos; FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::escape del tumor; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
Elsevier
Trends in Cancer;11(4)
https://doi.org/10.1016/j.trecan.2024.11.002
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
