dc.contributor
Institut Català de la Salut
dc.contributor
[Pérez de Val B, Vidal E] IRTA, Animal Health, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. WOAH Collaborating Centre for the Research and Control of Emerging and Re-Emerging Swine Diseases in Europe (IRTA-CReSA), Bellaterra, Spain. [Stuber T] National Veterinary Services Laboratories, U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, Ames, IA, USA. [Sáez JL] Subdirección General de Sanidad e Higiene Animal y Trazabilidad, Dirección General de Sanidad de la Producción Agraria, Ministerio de Agricultura, Pesca y Alimentación, Madrid, Spain. [Tórtola MT] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER of Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Pérez de Val, Bernat
dc.contributor.author
Vidal, Enric
dc.contributor.author
stuber, tod
dc.contributor.author
Sáez Llórente, José Luís
dc.contributor.author
Tórtola Fernández, María Teresa
dc.date.accessioned
2025-05-03T13:38:32Z
dc.date.available
2025-05-03T13:38:32Z
dc.date.issued
2025-04-02T12:51:47Z
dc.date.issued
2025-04-02T12:51:47Z
dc.identifier
Pérez de Val B, Vidal E, Stuber T, Sáez JL, Tórtola MT. Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface. One Heal. 2025 Jun;20:100993.
dc.identifier
http://hdl.handle.net/11351/12886
dc.identifier
10.1016/j.onehlt.2025.100993
dc.identifier.uri
http://hdl.handle.net/11351/12886
dc.description.abstract
Genomic epidemiology; Mycobacterium bovis; Zoonotic tuberculosis
dc.description.abstract
Epidemiologia genòmica; Mycobacterium bovis; Tuberculosi zoonòtica
dc.description.abstract
Epidemiología genómica; Mycobacterium bovis; Tuberculosis zoonótica
dc.description.abstract
This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of M. caprae transmission to humans. The study also revealed unexpected genetic diversity of mycobacteria within the same outbreak or even within the same patient, highlighting the complexity of tuberculosis transmission dynamics. The results underscore the value of genomic surveillance in understanding zoonotic TB transmission at the human-livestock interface and its role in informing effective control strategies.
dc.description.abstract
The study was funded by a grant of the European Commission (INNOTUB II – EFA115/01, Interreg POCTEFA 2021–2027 program, co-funded by the ERDF), the Department of Agriculture, Livestock, Fisheries and Food (DARPA) of the Government of Catalonia, and the Spanish Ministry of Agriculture, Fisheries and Food (MAPA). IRTA is supported by Centres de Recerca de Catalunya (CERCA) Programme / Generalitat de Catalunya (www.cerca.cat).
dc.format
application/pdf
dc.relation
One Health;20
dc.relation
https://doi.org/10.1016/j.onehlt.2025.100993
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Mycobacterium tuberculosis
dc.subject
Tuberculosi en els animals
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Tuberculosi - Transmissió
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Epidemiologia genètica
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ORGANISMS::Bacteria::Gram-Positive Bacteria::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium bovis
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DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis::Tuberculosis, Bovine
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PHENOMENA AND PROCESSES::Genetic Phenomena::Phylogeny
dc.subject
ORGANISMS::Bacteria::Gram-Positive Bacteria::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosis
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DISEASES::Bacterial Infections and Mycoses::Zoonoses
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology
dc.subject
ORGANISMOS::Bacteria::bacterias grampositivas::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium bovis
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Actinomycetales::micobacteriosis::tuberculosis::tuberculosis bovina
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FENÓMENOS Y PROCESOS::fenómenos genéticos::filogenia
dc.subject
ORGANISMOS::Bacteria::bacterias grampositivas::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosis
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::zoonosis
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::epidemiología molecular
dc.title
Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
