Sistema de Salut de Catalunya
Institut Català de la Salut
[Pérez de Val B, Vidal E] IRTA, Animal Health, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. WOAH Collaborating Centre for the Research and Control of Emerging and Re-Emerging Swine Diseases in Europe (IRTA-CReSA), Bellaterra, Spain. [Stuber T] National Veterinary Services Laboratories, U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, Ames, IA, USA. [Sáez JL] Subdirección General de Sanidad e Higiene Animal y Trazabilidad, Dirección General de Sanidad de la Producción Agraria, Ministerio de Agricultura, Pesca y Alimentación, Madrid, Spain. [Tórtola MT] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER of Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-04-02T12:51:47Z
2025-04-02T12:51:47Z
2025-06
Genomic epidemiology; Mycobacterium bovis; Zoonotic tuberculosis
Epidemiologia genòmica; Mycobacterium bovis; Tuberculosi zoonòtica
Epidemiología genómica; Mycobacterium bovis; Tuberculosis zoonótica
This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of M. caprae transmission to humans. The study also revealed unexpected genetic diversity of mycobacteria within the same outbreak or even within the same patient, highlighting the complexity of tuberculosis transmission dynamics. The results underscore the value of genomic surveillance in understanding zoonotic TB transmission at the human-livestock interface and its role in informing effective control strategies.
The study was funded by a grant of the European Commission (INNOTUB II – EFA115/01, Interreg POCTEFA 2021–2027 program, co-funded by the ERDF), the Department of Agriculture, Livestock, Fisheries and Food (DARPA) of the Government of Catalonia, and the Spanish Ministry of Agriculture, Fisheries and Food (MAPA). IRTA is supported by Centres de Recerca de Catalunya (CERCA) Programme / Generalitat de Catalunya (www.cerca.cat).
Article
Published version
English
Zoonosi; Mycobacterium tuberculosis; Tuberculosi en els animals; Tuberculosi - Transmissió; Bestiar boví; Filogènia; Epidemiologia genètica; ORGANISMS::Bacteria::Gram-Positive Bacteria::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium bovis; DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis::Tuberculosis, Bovine; PHENOMENA AND PROCESSES::Genetic Phenomena::Phylogeny; ORGANISMS::Bacteria::Gram-Positive Bacteria::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosis; DISEASES::Bacterial Infections and Mycoses::Zoonoses; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology; ORGANISMOS::Bacteria::bacterias grampositivas::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium bovis; ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Actinomycetales::micobacteriosis::tuberculosis::tuberculosis bovina; FENÓMENOS Y PROCESOS::fenómenos genéticos::filogenia; ORGANISMOS::Bacteria::bacterias grampositivas::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosis; ENFERMEDADES::infecciones bacterianas y micosis::zoonosis; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::epidemiología molecular
Elsevier
One Health;20
https://doi.org/10.1016/j.onehlt.2025.100993
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
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