Sistema de Salut de Catalunya
Institut Català de la Salut
[González-Díaz JM] UR Center for Mental Health, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Clinica Nuestra Señora de la Paz – OHSJD, Bogota, Colombia. Barcelona Clinic Schizophrenia Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain. Department of Medicine, School of Medicine, Institute of Neurosciences – UBNeuro, University of Barcelona, Barcelona, Spain. [Sánchez Dalmau B] Department of Ophthalmology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. [Camós-Carreras A] Department of Ophthalmology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. [Alba-Arbalat S] Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Department of Neurology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. [Amoretti S] Barcelona Clinic Schizophrenia Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain. Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Forte MF] Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-03-11T11:40:43Z
2025-03-11T11:40:43Z
2024
2025-03
Retina; Schizophrenia spectrum; Tomography
Retina; Espectre de l'esquizofrènia; Tomografia
Retina; Espectro de la esquizofrenia; Tomografía
Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional study investigates retinal thickness and its clinical correlations in a sample of early-course SSD patients compared to healthy controls (HCs). One hundred-two eyes from 26 SSD cases and 25 age- and sex-matched HCs were included. Retinal structure was evaluated using Spectral-Domain Optical Coherence Tomography (SD-OCT), focusing on the peripapillary retinal nerve fiber layer (pRNFL), macular volume/thickness, and ganglion cell-inner plexiform layer (GCL+IPL) thickness. Although SSD cases showed increased peripapillary retinal nerve fiber layer (pRNFL) thickness in specific quadrants, most retinal parameters did not differ significantly between groups. Preliminary associations were observed between retinal measures, premorbid adjustment, DUP, and cognitive performance. These findings, while suggesting the potential of retinal imaging as a tool for early detection and monitoring of psychotic disorders, must be interpreted with caution. Further longitudinal and multimodal research is warranted to explore the association between these retinal changes and neuroinflammation, neurodegeneration, and overall brain health in SSD patients.
JMG is funded by Ministerio de Ciencia y Tecnología – Colombia (Grant 885/2020). SA thanks the support of the Spanish Ministry of Innovation and Science (PI24/00671), funded by the Instituto de Salud Carlos III and cofinanced by the European Union (FEDER) “Una manera de hacer Europa”. MFF received the support of a “Contratos predoctorales de formación en investigación en salud (PFIS22) (FI22/00185) from the Instituto de Salud Carlos III (ISCIII). CT would like to thank Instituto de Salud Carlos III (ISCIII), PI17/01066, PI20/00344, PI24/00407, and co-funded by the European Union.
Article
Published version
English
Esquizofrènia - Imatgeria; Tomografia de coherència òptica; Retina - Imatgeria; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence; PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Schizophrenia Spectrum and Other Psychotic Disorders::Schizophrenia; Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging; ANATOMY::Sense Organs::Eye::Retina; Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica; PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::espectro de la esquizofrenia y otros trastornos psicóticos::esquizofrenia; Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen; ANATOMÍA::órganos de los sentidos::ojo::retina; Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
Elsevier
European Neuropsychopharmacology;92
https://doi.org/10.1016/j.euroneuro.2024.12.006
info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PI24%2F00671
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
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