Sistema de Salut de Catalunya
Institut Català de la Salut
[De Waele JJ] Department of Intensive Care Medicine, Ghent University Hospital,Ghent, Belgium. Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. [Coccolini F] General, Emergency and Trauma Surgery Department, Pisa University Hospital, Pisa, Italy. [Lagunes L] Grup de Recerca Clínica/Innovació en la Pneumònia i Sèpsia (CRIPS), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Facultad de Medicina, Universidad Autónoma de San Luis Potosi, San Luis Potosi, Mexico. [Maseda E] Department of Anesthesia and Critical Care, Hospital Quironsalud Valle del Henares, Madrid, Spain. Department of Pharmacology and Toxicology, Complutense University of Madrid, Madrid, Spain. [Rausei S] General Surgery Unit, Department of Surgery, Cittiglio-Angera Hospital, ASST SetteLaghi, Varese, Italy. [Rubio-Perez I] Colorectal Surgery Unit, Department of General Surgery, Hospital Universitario La Paz, Madrid, Spain. Hospital La Paz Institute for Health Research (Idipaz), Madrid, Spain. Universidad Autonoma de Madrid, Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
2024-01-24T08:24:30Z
2024-01-24T08:24:30Z
2023-12-08
Antibiotics; Nosocomial infection; Peritonitis
Antibiòtics; Infecció nosocomial; Peritonitis
Antibióticos; Infección nosocomial; Peritonitis
This comprehensive review aims to provide a practical guide for intensivists, focusing on enhancing patient care associated with nosocomial peritonitis (NP). It explores the epidemiology, diagnosis, and management of NP, a significant contributor to the mortality of surgical patients worldwide. NP is, per definition, a hospital-acquired condition and a consequence of gastrointestinal surgery or a complication of other diseases. NP, one of the most prevalent causes of sepsis in surgical Intensive Care Units (ICUs), is often associated with multi-drug resistant (MDR) bacteria and high mortality rates. Early clinical suspicion and the utilization of various diagnostic tools like biomarkers and imaging are of great importance. Microbiology is often complex, with antimicrobial resistance escalating in many parts of the world. Fungal peritonitis and its risk factors, diagnostic hurdles, and effective management approaches are particularly relevant in patients with NP. Contemporary antimicrobial strategies for treating NP are discussed, including drug resistance challenges and empirical antibiotic regimens. The importance of source control in intra-abdominal infection management, including surgical and non-surgical interventions, is also emphasized. A deeper exploration into the role of open abdomen treatment as a potential option for selected patients is proposed, indicating an area for further investigation. This review underscores the need for more research to advance the best treatment strategies for NP.
J.J.D.W. is supported by the Flanders Research Foundation (1881020N, Sr Clinical Investigator Grant).
Article
Published version
English
Septicèmia; Microorganismes - Resistència als medicaments; Peritonitis - Tractament; Medicaments antiinfecciosos - Ús terapèutic; DISEASES::Bacterial Infections and Mycoses::Infection::Intraabdominal Infections::Peritonitis; CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents; PHENOMENA AND PROCESSES::Microbiological Phenomena::Drug Resistance, Microbial; DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis; ENFERMEDADES::infecciones bacterianas y micosis::infección::infecciones intraabdominales::peritonitis; COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos; FENÓMENOS Y PROCESOS::fenómenos microbiológicos::farmacorresistencia microbiana; ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis
MDPI
Antibiotics;12(12)
https://doi.org/10.3390/antibiotics12121711
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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