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Title:
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Preparation of (S)-1-halo-2-octanols using ionic liquids and biocatalysts
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Author:
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Oromí Farrús, Mireia; Eras i Joli, Jordi; Sala i Martí, Núria; Torres i Grifo, Mercè; Canela i Garayoa, Ramon
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Notes:
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Preparation of (S)-1-chloro-2-octanol and (S)-1-bromo-2-octanol was carried out by the enzymatic hydrolysis of halohydrin palmitates using biocatalysts. Halohydrin
palmitates were prepared by various methods from palmitic acid and 1,2-octanediol. A
tandem hydrolysis was carried out using lipases from Candida antarctica (Novozym® 435),
Rhizomucor miehei (Lipozyme IM), and “resting cells” from a Rhizopus oryzae strain that was not mycotoxigenic. The influence of the enzyme and the reaction medium on the selective hydrolysis of isomeric mixtures of halohydrin esters is described. Novozym® 435 allowed preparation of (S)-1-chloro-2-octanol and (S)-1-bromo-2-octanol after 1–3 h ofreaction at 40 °C in [BMIM][PF6]. |
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Subject(s):
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-(S)-1-bromomethyl-1-heptanol
-(S)-1-chloromethyl-1-heptanol
-Lipases
-Enzymatic resolution
-Lipasa |
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Rights:
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cc-by, (c) Oromí-Farrús et al., 2009
http://creativecommons.org/licenses/by/3.0/es/deed.ca
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Document type:
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article
publishedVersion |
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Published by:
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Molecular Diversity Preservation International
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