Managing Blood Glucose in Premature Neonates via Parenteral Nutrition: In-silico Evaluation

Abstract

Prometeus (Preterm Brain-Oxygenation and Metabolic EU-Sensing: Feed the Brain) develops innovative technology for personalized nutrition in premature neonates. Central to this is the Nutritional Clinical Advisor, an adaptive algorithm providing optimal parenteral nutrition plans to enhance brain oxygenation. This study tests a closed-loop PID controller for regulating glucose levels in virtual neonates born preterm, offering insights into its effectiveness and guiding future NCA development to support neonatal care

The authors would like to express their gratitude to all the physicians involved in the Prometeus project for their valuable discussions and insights during its development